A novel somatic mutation 145-147delETEinsK in KCNJ5 increases aldosterone production
文献类型：期刊论文
| 作者 | Zheng, F-F1,2,3,4; Zhu, L-M1,2,3; Zhang, Y.1,2,3; Li, M-Y1,2,3; Wang, J-G1,2,3; Zhu, D-L1,2,3; Gao, P-J1,2,3; Zhou, W-L5,6; Zhu, Y-C7; Gao, P-J8,9 |
| 刊名 | JOURNAL OF HUMAN HYPERTENSION
 |
| 出版日期 | 2017 |
| 卷号 | 31期号:11页码:756-759 |
| 关键词 | microRNA transforming growth factor-beta Smad4 fibrosis muscle |
| ISSN号 | 0950-9240 |
| DOI | 10.1038/jhh.2017.50 |
| 文献子类 | Article |
| 英文摘要 | A novel KCNJ5 mutation (145 - 147delETEinsK) was detected in a female patient with aldosterone-producing adenoma. The mutation resulted in increased aldosterone production in the absence or presence of angiotensin II. Loss of K+ selectivity, increased Na+ conductance, membrane depolarization and Ca2+ influx were involved in the process. |
| 学科主题 | Cardiovascular System & Cardiology |
| WOS关键词 | K+ CHANNEL MUTATIONS ; POTASSIUM CHANNEL ; HYPERTENSION ; SELECTIVITY ; ADENOMAS |
| 语种 | 英语 |
| WOS记录号 | WOS:000412222300013 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1193]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Ruijin Hosp, State Key Lab Med Genom, Shanghai Key Lab Hypertens, Shanghai, Peoples R China; 2.Ruijin Hosp, Dept Hypertens, Shanghai, Peoples R China; 3.Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Hypertens, Shanghai, Peoples R China; 4.Tongji Univ Med, Dept Cardiol, Tongji Hosp, Shanghai, Peoples R China; 5.Shanghai Jiao Tong Univ, Dept Urol, Sch Med, Ruijin Hosp, Shanghai, Peoples R China; 6.Shanghai Jiao Tong Univ, Dept Urol, Sch Med, Ruijin Hosp,Luwan Branch, Shanghai, Peoples R China; 7.Fudan Univ, Dept Physiol & Pathophysiol, Shanghai Med Coll, Shanghai, Peoples R China; 8.Chinese Acad Sci, Shanghai Inst Biol Sci, Lab Vasc Biol, Inst Hlth Sci, Shanghai, Peoples R China; 9.Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Stem Cell Biol, Inst Hlth Sci, Shanghai, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Zheng, F-F,Zhu, L-M,Zhang, Y.,et al. A novel somatic mutation 145-147delETEinsK in KCNJ5 increases aldosterone production[J]. JOURNAL OF HUMAN HYPERTENSION,2017,31(11):756-759. |
| APA | Zheng, F-F.,Zhu, L-M.,Zhang, Y..,Li, M-Y.,Wang, J-G.,...&,.(2017).A novel somatic mutation 145-147delETEinsK in KCNJ5 increases aldosterone production.JOURNAL OF HUMAN HYPERTENSION,31(11),756-759. |
| MLA | Zheng, F-F,et al."A novel somatic mutation 145-147delETEinsK in KCNJ5 increases aldosterone production".JOURNAL OF HUMAN HYPERTENSION 31.11(2017):756-759. |
入库方式： OAI收割
来源：上海营养与健康研究所
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