A Genome-Wide Association Study of Basal Transepidermal Water Loss Finds that Variants at 9q34.3 Are Associated with Skin Barrier Function
文献类型：期刊论文
| 作者 | Zhang, Manfei1,2,3; Tan, Jingze1,2; Yang, Yajun1,2; Zhang, Juan1,2; Li, Hui1,2; Jin, Li1,2,3; Wang, Sijia1,2,3; Li, Bingjie3; Wu, Sijie3,4; Li, Bingjie4 |
| 刊名 | JOURNAL OF INVESTIGATIVE DERMATOLOGY
 |
| 出版日期 | 2017 |
| 卷号 | 137期号:4页码:979-982 |
| 关键词 | colorectal cancer miR-449a SATB2 tumorigenesis |
| ISSN号 | 0022-202X |
| DOI | 10.1016/j.jid.2016.11.030 |
| 文献子类 | Letter |
| 英文摘要 | miR-449a has been reported to act as a tumor suppressor in several cancers, however, it is controversial whether it inhibits tumor growth in colorectal cancer. The mechanisms underlying its expression and functions in colorectal cancers are still largely unknown. SATB2 is a sensitive and specific marker for CRC diagnosis. However, the mechanisms by which the expression and functions of SATB2 are regulated still remain to be clarified. We investigated the expression and functional significance of miR-449a and SATB2 and the mechanisms of their dysregulation in human CRC cells. miR-449a overexpression or SATB2 depletion inhibited tumor growth and promoted apoptosis in colorectal tumor cells in vitro and in xenograft mouse model, partially by downregulating SATB2. Expression of miR-449a was increased epigenetically via knocking down their targets, particularly SATB2. miR-449a was downregulated and STAB2 expression was upregulated in human CRCs. Their expressions were significantly associated with overall survival of CRC patients. Our findings demonstrate the existence of a miR-449a-SATB2 negative feedback loop that maintains low levels of miR-449a as well as high level of SATB2, thereby promoting CRC development. |
| 学科主题 | Dermatology |
| WOS关键词 | IN-VIVO ; DYNAMICS |
| 语种 | 英语 |
| WOS记录号 | WOS:000396884400034 |
| 出版者 | ELSEVIER SCIENCE INC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1195]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Fudan Univ, Minist Educ, Collaborat Innovat Ctr Genet & Dev, Sch Life Sci,Key Lab Contemporary Anthropol, Shanghai 200438, Peoples R China; 2.Fudan Univ, State Key Lab Genet Engn, Collaborat Innovat Ctr Genet & Dev, Sch Life Sci, Shanghai 200438, Peoples R China; 3.Chinese Acad Sci, Key Lab Computat Biol, CAS MPG Partner Inst Computat Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China; 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 5.Fudan Taizhou Inst Hlth Sci, 1 Yaocheng Rd, Taizhou 225300, Jiangsu, Peoples R China; 6.IUF Leibniz Res Inst Environm Med, Dusseldorf, Germany, |
| 推荐引用方式 GB/T 7714 | Zhang, Manfei,Tan, Jingze,Yang, Yajun,et al. A Genome-Wide Association Study of Basal Transepidermal Water Loss Finds that Variants at 9q34.3 Are Associated with Skin Barrier Function[J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY,2017,137(4):979-982. |
| APA | Zhang, Manfei.,Tan, Jingze.,Yang, Yajun.,Zhang, Juan.,Li, Hui.,...&,.(2017).A Genome-Wide Association Study of Basal Transepidermal Water Loss Finds that Variants at 9q34.3 Are Associated with Skin Barrier Function.JOURNAL OF INVESTIGATIVE DERMATOLOGY,137(4),979-982. |
| MLA | Zhang, Manfei,et al."A Genome-Wide Association Study of Basal Transepidermal Water Loss Finds that Variants at 9q34.3 Are Associated with Skin Barrier Function".JOURNAL OF INVESTIGATIVE DERMATOLOGY 137.4(2017):979-982. |
入库方式： OAI收割
来源：上海营养与健康研究所
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