A joint adventure of Sino-German researchers to explore the wild world of RNAs
文献类型：期刊论文
| 作者 | Bindereif, Albrecht1; Wang, Zefeng2,3,4; , |
| 刊名 | JOURNAL OF MOLECULAR CELL BIOLOGY
 |
| 出版日期 | 2019 |
| 卷号 | 11期号:10页码:811-812 |
| 关键词 | Acute myocardial infarction Qishenyiqi anti-inflammation dyslipidaemia group significance analysis |
| ISSN号 | 1674-2788 |
| DOI | 10.1093/jmcb/mjz097 |
| 文献子类 | Editorial Material |
| 英文摘要 | Background: Based on global gene expression profile, therapeutic effects of Qishenyiqi (QSYQ) on acute myocardial infarction (AMI) were investigated by integrated analysis at multiple levels including gene expression, pathways involved and functional group. Methods: Sprague-Dawley (SD) rats were randomly divided into 3 groups: Sham-operated, AMI model (left anterior descending coronary artery ligation) and QSYQ-treated group. Cardiac tissues were obtained for analysing digital gene expression. Sequencing and transcriptome analyses were performed collaboratively, including analyses of differential gene expression, gene co-expression network, targeted attack on network and functional grouping. In this study, a new strategy known as keystone gene-based group significance analysis was also developed. Results: Analysis of top keystone QSYQ-regulated genes indicated that QSYQ ameliorated ventricular remodeling (VR), which is an irreversible process in the pathophysiology of AMI. At pathway level, both well-known cardiovascular diseases and cardiac signaling pathways were enriched. The most remarkable finding was the novel therapeutic effects identified from functional group analysis. This included anti-inflammatory effects mediated via suppression of arachidonic acid lipoxygenase (LOX) pathway and elevation of nitric oxide (NO); and amelioration of dyslipidaemia mediated via fatty acid oxidation. The regulatory patterns of QSYQ on key genes were confirmed by western blot, immunohistochemistry analysis and measurement of plasma lipids, which further validated the therapeutic effects of QSYQ proposed in this study. Conclusions: QSYQ exerts multipronged therapeutic effects on AMI, by concurrently alleviating VR progression, attenuating inflammation induced by arachidonic acid LOX pathway and NO production; and ameliorating dyslipidaemia. |
| 学科主题 | Pharmacology & Pharmacy |
| WOS关键词 | ARACHIDONIC-ACID METABOLISM ; HEART-DISEASE ; CARDIOVASCULAR-DISEASE ; LIPOPROTEIN-LIPASE ; CHOLESTEROL ; EXPRESSION ; PLASMA ; RISK ; LEUKOTRIENES ; INFLAMMATION |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31638144 |
| WOS记录号 | WOS:000505828900001 |
| 出版者 | OXFORD UNIV PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1200]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Justus Liebig Univ Giessen, Inst Biochem, Dept Biol & Chem, D-35392 Giessen, Germany; 2.Chinese Acad Sci, Shanghai Inst Nutr & Hlth, CAS Key Lab Computat Biol, Biomed Big Data Ctr,CAS MPG Partner Inst Computat, Shanghai 200031, Peoples R China; 3.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai 200031, Peoples R China; 4.Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Shanghai 200031, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Bindereif, Albrecht,Wang, Zefeng,,. A joint adventure of Sino-German researchers to explore the wild world of RNAs[J]. JOURNAL OF MOLECULAR CELL BIOLOGY,2019,11(10):811-812. |
| APA | Bindereif, Albrecht,Wang, Zefeng,&,.(2019).A joint adventure of Sino-German researchers to explore the wild world of RNAs.JOURNAL OF MOLECULAR CELL BIOLOGY,11(10),811-812. |
| MLA | Bindereif, Albrecht,et al."A joint adventure of Sino-German researchers to explore the wild world of RNAs".JOURNAL OF MOLECULAR CELL BIOLOGY 11.10(2019):811-812. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。