IRES-mediated cap-independent translation, a path leading to hidden proteome
文献类型：期刊论文
| 作者 | Yang, Yun2; Wang, Zefeng2; Wang, Zefeng1,3; , |
| 刊名 | JOURNAL OF MOLECULAR CELL BIOLOGY
 |
| 出版日期 | 2019 |
| 卷号 | 11期号:10页码:911-919 |
| 关键词 | IRES ITAF translation bicistronic system circular RNA |
| ISSN号 | 1674-2788 |
| DOI | 10.1093/jmcb/mjz091 |
| 文献子类 | Review |
| 英文摘要 | Most eukaryotic mRNAs are translated in a cap-dependent fashion; however, under stress conditions, the cap-independent translation driven by internal ribosomal entry sites (IRESs) can serve as an alternative mechanism for protein production. Many IRESs have been discovered from viral or cellular mRNAs to promote ribosome assembly and initiate translation by recruiting different trans-acting factors. Although the mechanisms of translation initiation driven by viral IRESs are relatively well understood, the existence of cellular IRESs is still under debate due to the limitations of translation reporter systems used to assay IRES activities. A recent screen identified > 1000 putative IRESs from viral and human mRNAs, expanding the scope and mechanism for cap-independent translation. Additionally, a large number of circular RNAs lacking free ends were identified in eukaryotic cells, many of which are found to be translated through IRESs. These findings suggest that IRESs may play a previously unappreciated role in driving translation of the new type of mRNA, implying a hidden proteome produced from cap-independent translation. |
| 学科主题 | Geriatrics & Gerontology ; Neurosciences & Neurology |
| WOS关键词 | RIBOSOME ENTRY SITE ; HEPATITIS-C VIRUS ; TRANS-ACTING FACTORS ; TRACT-BINDING-PROTEIN ; OPEN READING FRAMES ; 5 NONCODING REGION ; CIRCULAR RNAS ; INTERNAL INITIATION ; IN-VITRO ; ENCEPHALOMYOCARDITIS VIRUS |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31504667 |
| WOS记录号 | WOS:000505828900011 |
| 出版者 | OXFORD UNIV PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1201]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai 200031, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Nutr & Hlth, CAS MPG Partner Inst Computat Biol, CAS Key Lab Computat Biol,Biomed Big Data Ctr, Shanghai 200031, Peoples R China; 3.Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Shanghai 200031, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Yang, Yun,Wang, Zefeng,Wang, Zefeng,et al. IRES-mediated cap-independent translation, a path leading to hidden proteome[J]. JOURNAL OF MOLECULAR CELL BIOLOGY,2019,11(10):911-919. |
| APA | Yang, Yun,Wang, Zefeng,Wang, Zefeng,&,.(2019).IRES-mediated cap-independent translation, a path leading to hidden proteome.JOURNAL OF MOLECULAR CELL BIOLOGY,11(10),911-919. |
| MLA | Yang, Yun,et al."IRES-mediated cap-independent translation, a path leading to hidden proteome".JOURNAL OF MOLECULAR CELL BIOLOGY 11.10(2019):911-919. |
入库方式： OAI收割
来源：上海营养与健康研究所
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