Sarm1 Gene Deficiency Attenuates Diabetic Peripheral Neuropathy in Mice
文献类型：期刊论文
| 作者 | Cheng, Yalan2; Liu, Jun2; Luan, Yi2; Liu, Zhiyuan2; Lai, Hejin2; Zhong, Wuling2; Yang, Yale2; Yu, Huimin2; Feng, Ning2; Wang, Hui2 |
| 刊名 | DIABETES
 |
| 出版日期 | 2019 |
| 卷号 | 68期号:11页码:2120-2130 |
| 关键词 | nanodiamonds protein delivery oral delivery stem cells microenvironment intestinal remodeling |
| ISSN号 | 0012-1797 |
| DOI | 10.2337/db18-1233 |
| 文献子类 | Article |
| 英文摘要 | Diabetic peripheral neuropathy (DPN) is the most common complication in both type 1 and type 2 diabetes, but any treatment toward the development of DPN is not yet available. Axon degeneration is an early feature of many peripheral neuropathies, including DPN. Delay of axon degeneration has beneficial effects on various neurodegenerative diseases, but its effect on DPN is yet to be elucidated. Deficiency of Sarm1 significantly attenuates axon degeneration in several models, but the effect of Sarm1 deficiency on DPN is still unclear. In this study, we show that Sarm1 knockout mice exhibit normal glucose metabolism and pain sensitivity, and deletion of the Sarm1 gene alleviates hypoalgesia in streptozotocin-induced diabetic mice. Moreover, Sarm1 gene deficiency attenuates intraepidermal nerve fiber loss in footpad skin; alleviates axon degeneration, the change of g-ratio in sciatic nerves, and NAD(+) decrease; and relieves axonal outgrowth retardation of dorsal root ganglia from diabetic mice. In addition, Sarm1 gene deficiency markedly diminishes the changes of gene expression profile induced by streptozotocin in the sciatic nerve, especially some abundant genes involved in neurodegenerative diseases. These findings demonstrate that Sarm1 gene deficiency attenuates DPN in mice and suggest that slowing down axon degeneration is a potential promising strategy to combat DPN. |
| 学科主题 | Science & Technology - Other Topics ; Materials Science |
| WOS关键词 | WALLERIAN DEGENERATION ; AXON DEGENERATION ; NERVE-CONDUCTION ; ALDOSE REDUCTASE ; SCIATIC-NERVES ; PROTEIN ; ACTIVATION ; PATHWAY ; INJURY ; DEHYDROGENASE |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31439642 |
| WOS记录号 | WOS:000491455200007 |
| 出版者 | AMER DIABETES ASSOC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1204]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China, 2.Chinese Acad Sci, CAS Key Lab Nutr Metab & Food Safety, CAS Ctr Excellence Mol Cell Sci,Shanghai Inst Nut, Univ Chinese Acad Sci,Shanghai Inst Biol Sci, Shanghai, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Cheng, Yalan,Liu, Jun,Luan, Yi,et al. Sarm1 Gene Deficiency Attenuates Diabetic Peripheral Neuropathy in Mice[J]. DIABETES,2019,68(11):2120-2130. |
| APA | Cheng, Yalan.,Liu, Jun.,Luan, Yi.,Liu, Zhiyuan.,Lai, Hejin.,...&,.(2019).Sarm1 Gene Deficiency Attenuates Diabetic Peripheral Neuropathy in Mice.DIABETES,68(11),2120-2130. |
| MLA | Cheng, Yalan,et al."Sarm1 Gene Deficiency Attenuates Diabetic Peripheral Neuropathy in Mice".DIABETES 68.11(2019):2120-2130. |
入库方式： OAI收割
来源：上海营养与健康研究所
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