Long-term di (2-ethylhexyl)-phthalate exposure promotes proliferation and survival of HepG2 cells via activation of NF kappa B
文献类型：期刊论文
| 作者 | Wei, Ning; Feng, Xiaoyan; Xie, Zhiqin; Zhang, Yanan; Feng, Ying; , |
| 刊名 | TOXICOLOGY IN VITRO
 |
| 出版日期 | 2017 |
| 卷号 | 42期号:-页码:86-92 |
| 关键词 | DEHP Proliferation Inflammation NF kappa B |
| ISSN号 | 0887-2333 |
| DOI | 10.1016/j.tiv.2017.04.015 |
| 文献子类 | Article |
| 英文摘要 | Di (2-ethylhexyl)-phthalate (DEHP) is the most commonly used plasticizer. DEHP can easily leach out from products into the environment and has become a significant environmental contamination. However, its carcinogenic effects in human remain controversial. In this study, we exposed hepatocellular carcinoma HepG2 cells to different concentrations of DEHP for a period of times, followed by a combination of RNA-seq analysis and molecular analysis for DEHP-altered genes. We observed that long-term and very low-dose DEHP treatment has growth-inducing activity in HepG2 cells, while short-term and high-dose DEHP treatment has little effects on tumor cell proliferation. Bioinformatic analysis further revealed that a large subset of differentially expressed genes affected by DEHP have functional annotations related to inflammation response. Importantly we found that long-term DEHP treatment stimulated nuclear factor-kappa B (NF-kappa B) activity in HepG2 cells, while inhibition of NF kappa B activity could offset the effects of DEHP exposure. In conclusion, continuous DEHP treatment could promote proliferation of HepG2 cells via activating NF kappa B signaling pathway. |
| 学科主题 | Toxicology |
| WOS关键词 | COLON-CANCER CELLS ; DI(2-ETHYLHEXYL) PHTHALATE ; PEROXISOME PROLIFERATOR ; IN-VITRO ; DEHP ; PATHWAY ; INFLAMMATION ; PLASTICIZER ; METABOLITES ; CHEMICALS |
| 语种 | 英语 |
| WOS记录号 | WOS:000404304900011 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1205]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | Chinese Acad Sci, Key Lab food safety Res, Inst Nutr Sci, Shanghai Inst Biol Sci, Shanghai, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Wei, Ning,Feng, Xiaoyan,Xie, Zhiqin,et al. Long-term di (2-ethylhexyl)-phthalate exposure promotes proliferation and survival of HepG2 cells via activation of NF kappa B[J]. TOXICOLOGY IN VITRO,2017,42(-):86-92. |
| APA | Wei, Ning,Feng, Xiaoyan,Xie, Zhiqin,Zhang, Yanan,Feng, Ying,&,.(2017).Long-term di (2-ethylhexyl)-phthalate exposure promotes proliferation and survival of HepG2 cells via activation of NF kappa B.TOXICOLOGY IN VITRO,42(-),86-92. |
| MLA | Wei, Ning,et al."Long-term di (2-ethylhexyl)-phthalate exposure promotes proliferation and survival of HepG2 cells via activation of NF kappa B".TOXICOLOGY IN VITRO 42.-(2017):86-92. |
入库方式： OAI收割
来源：上海营养与健康研究所
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