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miR-449a inhibits colorectal cancer progression by targeting SATB2

文献类型：期刊论文

作者Sun, Xiaohua2,3; Liu, Sanhong2,3; Chen, Pengfei2,3; Liu, Zhi2,3; Jiang, Yuhang2,3; Cao, Xinwei2,3; Cheng, Chunyan2,3; Chen, Xi2,3; Tao, Yu2,3; Li, Cuifeng2,3
刊名ONCOTARGET
出版日期2017
卷号8期号:60页码:100975-100988
关键词colorectal cancer miR-449a SATB2 tumorigenesis
ISSN号1949-2553
DOI10.18632/oncotarget.10900
文献子类Article
英文摘要miR-449a has been reported to act as a tumor suppressor in several cancers, however, it is controversial whether it inhibits tumor growth in colorectal cancer. The mechanisms underlying its expression and functions in colorectal cancers are still largely unknown. SATB2 is a sensitive and specific marker for CRC diagnosis. However, the mechanisms by which the expression and functions of SATB2 are regulated still remain to be clarified. We investigated the expression and functional significance of miR-449a and SATB2 and the mechanisms of their dysregulation in human CRC cells. miR-449a overexpression or SATB2 depletion inhibited tumor growth and promoted apoptosis in colorectal tumor cells in vitro and in xenograft mouse model, partially by downregulating SATB2. Expression of miR-449a was increased epigenetically via knocking down their targets, particularly SATB2. miR-449a was downregulated and STAB2 expression was upregulated in human CRCs. Their expressions were significantly associated with overall survival of CRC patients. Our findings demonstrate the existence of a miR-449a-SATB2 negative feedback loop that maintains low levels of miR-449a as well as high level of SATB2, thereby promoting CRC development.
学科主题Oncology ; Cell Biology
WOS关键词OSTEOBLAST DIFFERENTIATION ; TUMOR-SUPPRESSOR ; GENE-EXPRESSION ; PROSTATE-CANCER ; CELLS ; CARCINOMA ; APOPTOSIS ; PROLIFERATION ; SURVIVAL ; MIR-34A
语种英语
WOS记录号WOS:000419533200002
出版者IMPACT JOURNALS LLC
版本出版稿
源URL[http://202.127.25.144/handle/331004/1208]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China,
2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai 200031, Peoples R China;
3.Shanghai Jiao Tong Univ, Sch Med, Shanghai 200031, Peoples R China;
4.Shanghai Jiao Tong Univ, Sch Med, Collaborat Innovat Ctr Syst Biomed, Shanghai 200240, Peoples R China;
5.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 200031, Peoples R China;
6.Fudan Univ, Zhongshan Hosp, Dept Pathol, Shanghai 200032, Peoples R China;
7.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Gen Surg Dept, Shanghai 200025, Peoples R China;
8.Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Nucl Med, Shanghai 200072, Peoples R China;
9.China Japan Union Hosp, Ctr Sci Res, Tissue Bank, Changchun 130033, Jilin, Peoples R China;
推荐引用方式
GB/T 7714		 Sun, Xiaohua,Liu, Sanhong,Chen, Pengfei,et al. miR-449a inhibits colorectal cancer progression by targeting SATB2[J]. ONCOTARGET,2017,8(60):100975-100988.
APA Sun, Xiaohua.,Liu, Sanhong.,Chen, Pengfei.,Liu, Zhi.,Jiang, Yuhang.,...&,.(2017).miR-449a inhibits colorectal cancer progression by targeting SATB2.ONCOTARGET,8(60),100975-100988.
MLA Sun, Xiaohua,et al."miR-449a inhibits colorectal cancer progression by targeting SATB2".ONCOTARGET 8.60(2017):100975-100988.

入库方式： OAI收割

来源：上海营养与健康研究所

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