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MiR-125a Is a critical modulator for neutrophil development

文献类型：期刊论文

作者Qin, Yuting2,3; Wu, Lingling2,3; Ouyang, Ye2,3; Zhou, Ping2,3; Zhou, Haibo2,3; Ma, Jianyang2,3; Chen, Yanan2,3; Qian, Jie2,3; Tang, Yuanjia2,3; Shen, Nan2,3,4,5
刊名PLOS GENETICS
出版日期2017
卷号13期号:10页码:e1007027
关键词cancer-associated cachexia adipose tissue loss long noncoding RNAs adipogenesis HuR
ISSN号1553-7404
DOI10.1371/journal.pgen.1007027
文献子类Article
英文摘要MicroRNAs are universal post-transcriptional regulators in genomes. They have the ability of buffering gene expressional programs, contributing to robustness of biological systems and playing important roles in development, physiology and diseases. Here, we identified a microRNA, miR-125a, as a positive regulator of granulopoiesis. MiR125a knockout mice show reduced infiltration of neutrophils in the lung and alleviated tissue destruction after endotoxin challenge as a consequence of decreased neutrophil numbers. Furthermore, we demonstrated that this significant reduction of neutrophils was due to impaired development of granulocyte precursors to mature neutrophils in an intrinsic manner. We showed that Socs3, a critical repressor for granulopoiesis, was a target of miR-125a. Overall, our study revealed a new microRNA regulating granulocyte development and supported a model in which miR-125a acted as a fine-tuner of granulopoiesis.
学科主题Genetics & Heredity
WOS关键词COLONY-STIMULATING FACTOR ; PHYSIOLOGICAL NEGATIVE REGULATOR ; EMERGENCY GRANULOPOIESIS ; TRANSCRIPTION FACTOR ; MICRORNA CONTROL ; BONE-MARROW ; GRANULOCYTE ; CELLS ; SOCS3 ; DIFFERENTIATION
语种英语
WOS记录号WOS:000414161300008
出版者PUBLIC LIBRARY SCIENCE
版本出版稿
源URL[http://202.127.25.144/handle/331004/1210]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Cincinnati Childrens Hosp Med Ctr, CAGE, Cincinnati, OH 45229 USA;
2.Shanghai Jiao Tong Univ, Sch Med, Dept Rheumatol, Renji Hosp, Shanghai, Peoples R China;
3.Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Rheumatol, Renji Hosp, Shanghai, Peoples R China;
4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai, Peoples R China;
5.Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China;
6.Renji Hosp, Shanghai Canc Inst, State Key Lab Oncogenes & Related Genes, Shanghai, Peoples R China;
7.Shanghai Jiao Tong Univ, Sch Med, Collaborat Innovat Ctr Translat Med, Shanghai, Peoples R China;
8.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, China Australia Ctr Personalised Immunol, Shanghai, Peoples R China,
推荐引用方式
GB/T 7714		 Qin, Yuting,Wu, Lingling,Ouyang, Ye,et al. MiR-125a Is a critical modulator for neutrophil development[J]. PLOS GENETICS,2017,13(10):e1007027.
APA Qin, Yuting.,Wu, Lingling.,Ouyang, Ye.,Zhou, Ping.,Zhou, Haibo.,...&,.(2017).MiR-125a Is a critical modulator for neutrophil development.PLOS GENETICS,13(10),e1007027.
MLA Qin, Yuting,et al."MiR-125a Is a critical modulator for neutrophil development".PLOS GENETICS 13.10(2017):e1007027.

入库方式： OAI收割

来源：上海营养与健康研究所

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