Lipidome determinants of maximal lifespan in mammals
文献类型：期刊论文
| 作者 | Bozek, Katarzyna1,2,13; Khaitovich, Philipp1,2,3; Paeaebo, Svante2; Khrameeva, Ekaterina E.3,4; Reznick, Jane5; Omerbasic, Damir6; Lewin, Gary R.6; Bennett, Nigel C.7; Azpurua, Jorge8; Gorbunova, Vera8 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:-页码:5 |
| 关键词 | complete gene knockout CRISPR/Cas9 multiple sgRNAs |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-017-00037-7 |
| 文献子类 | Article |
| 英文摘要 | Maximal lifespan of mammalian species, even if closely related, may differ more than 10-fold, however the nature of the mechanisms that determine this variability is unresolved. Here, we assess the relationship between maximal lifespan duration and concentrations of more than 20,000 lipid compounds, measured in 669 tissue samples from 6 tissues of 35 species representing three mammalian clades: primates, rodents and bats. We identify lipids associated with species' longevity across the three clades, uncoupled from other parameters, such as basal metabolic rate, body size, or body temperature. These lipids clustered in specific lipid classes and pathways, and enzymes linked to them display signatures of greater stabilizing selection in long-living species, and cluster in functional groups related to signaling and protein-modification processes. These findings point towards the existence of defined molecular mechanisms underlying variation in maximal lifespan among mammals. |
| 学科主题 | Science & Technology - Other Topics |
| WOS关键词 | FATTY-ACID UNSATURATION ; SIGNALING PATHWAY ; OXIDATIVE STRESS ; METABOLIC-RATE ; PLASMA-LEVELS ; LONGEVITY ; MICE ; ADAPTATION ; RESISTANCE ; MORTALITY |
| 语种 | 英语 |
| WOS记录号 | WOS:000396938100004 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1212]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.CAS MPG Partner Inst Computat Biol, CAS Key Lab Computat Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China; 2.Max Planck Inst Evolutionary Anthropol, Deutsch Pl 6, D-04103 Leipzig, Germany; 3.Skolkovo Inst Sci & Technol, Skoltech Ctr Computat & Syst Biol, Novaya St 100, Skolkovo 143025, Russia; 4.Russian Acad Sci, Inst Informat Transmiss Problems, Bolshoy Karetny 19-1, Moscow 127051, Russia; 5.Univ Pretoria, Dept Zool & Entomol, Max Delbruck Ctr Mol Med, Pretoria, South Africa; 6.Max Delbruck Ctr Mol Med, Robert Rossle Str 10, D-13092 Berlin, Germany; 7.Univ Pretoria, Dept Zool & Entomol, Pretoria, South Africa; 8.Univ Rochester, 434 Hutchison Hall, Rochester, NY 14627 USA; 9.Univ Louis Pasteur, SILABE, Primatol Ctr, 4 Rue Blaise Pascal, F-67070 Strasbourg, France; 10.CNRS, MNHN, UMR 7179, 1 Ave Petit Chateu, F-91800 Brunoy, France; |
| 推荐引用方式 GB/T 7714 | Bozek, Katarzyna,Khaitovich, Philipp,Paeaebo, Svante,et al. Lipidome determinants of maximal lifespan in mammals[J]. SCIENTIFIC REPORTS,2017,7(-):5. |
| APA | Bozek, Katarzyna.,Khaitovich, Philipp.,Paeaebo, Svante.,Khrameeva, Ekaterina E..,Reznick, Jane.,...&,.(2017).Lipidome determinants of maximal lifespan in mammals.SCIENTIFIC REPORTS,7(-),5. |
| MLA | Bozek, Katarzyna,et al."Lipidome determinants of maximal lifespan in mammals".SCIENTIFIC REPORTS 7.-(2017):5. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。