Mediator MED23 Links Pigmentation and DNA Repair through the Transcription Factor MITF
文献类型：期刊论文
| 作者 | Xia, Min1; Chen, Kun1; Yao, Xiao1; Wang, Gang1,2; Chen, Kun2; Xu, Yichi3; Yao, Jiaying3; Yan, Jun3; Shao, Zhen3; , |
| 刊名 | CELL REPORTS
 |
| 出版日期 | 2017 |
| 卷号 | 20期号:8页码:1794-1804 |
| ISSN号 | 2211-1247 |
| DOI | 10.1016/j.celrep.2017.07.056 |
| 文献子类 | Article |
| 英文摘要 | DNA repair is related to many physiological and pathological processes, including pigmentation. Little is known about the role of the transcriptional cofactor Mediator complex in DNA repair and pigmentation. Here, we demonstrate that Mediator MED23 plays an important role in coupling UV-induced DNA repair to pigmentation. The loss of Med23 specifically impairs the pigmentation process in melanocyte-lineage cells and in zebrafish. Med23 deficiency leads to enhanced nucleotide excision repair (NER) and less DNA damage following UV radiation because of the enhanced expression and recruitment of NER factors to chromatin for genomic stability. Integrative analyses of melanoma cells reveal that MED23 controls the expression of a melanocyte master regulator, Mitf, by modulating its distal enhancer activity, leading to opposing effects on pigmentation and DNA repair. Collectively, the Mediator MED23/MITF axis connects DNA repair to pigmentation, thus providing molecular insights into the DNA damage response and skin-related diseases. |
| 学科主题 | Cell Biology |
| WOS关键词 | EMBRYONIC STEM-CELLS ; XERODERMA-PIGMENTOSUM ; COACTIVATOR COMPLEX ; EXCISION-REPAIR ; MELANOMA ; SUBUNIT ; DIFFERENTIATION ; MELANOCYTES ; DAMAGE ; MELANOGENESIS |
| 语种 | 英语 |
| WOS记录号 | WOS:000408154300006 |
| 出版者 | CELL PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1213]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Cell Biol,CAS Ctr Excellence Mol Ce, 320 Yueyang Rd, Shanghai 200031, Peoples R China; 2.ShanghaiTech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Shanghai 200031, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Xia, Min,Chen, Kun,Yao, Xiao,et al. Mediator MED23 Links Pigmentation and DNA Repair through the Transcription Factor MITF[J]. CELL REPORTS,2017,20(8):1794-1804. |
| APA | Xia, Min.,Chen, Kun.,Yao, Xiao.,Wang, Gang.,Chen, Kun.,...&,.(2017).Mediator MED23 Links Pigmentation and DNA Repair through the Transcription Factor MITF.CELL REPORTS,20(8),1794-1804. |
| MLA | Xia, Min,et al."Mediator MED23 Links Pigmentation and DNA Repair through the Transcription Factor MITF".CELL REPORTS 20.8(2017):1794-1804. |
入库方式： OAI收割
来源：上海营养与健康研究所
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