BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration
文献类型：期刊论文
| 作者 | Liu, Min1,2,3; Li, Li1,2,3; Gao, Wei-Qiang1,2,3; Sun, Tongyu4; Li, Ni4; Peng, Junjie5; Fu, Da6; Li, Wei7; , |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2019 |
| 卷号 | 10期号:-页码:4614 |
| 关键词 | Hepatocyte-like cells Human pluripotent stem cells Hepatic differentiation Biomedical application |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/s41467-019-12573-z |
| 文献子类 | Article |
| 英文摘要 | Autophagy is a central component of integrated stress responses that influences many inflammatory diseases, including inflammatory bowel disease (IBD) and colorectal cancer (CRC). While the core machinery is known, the molecular basis of the epigenetic regulation of autophagy and its role in colon inflammation remain largely undefined. Here, we report that BRG1, an ATPase subunit of the SWI/SNF chromatin remodeling complex, is required for the homeostatic maintenance of intestinal epithelial cells (IECs) to prevent the inflammation and tumorigenesis. BRG1 emerges as a key regulator that directly governs the transcription of Atg16l1, Ambra1, Atg7 and Wipi2, which are important for autophagosome biogenesis. Defective autophagy in BRG1-deficient IECs results in excess reactive oxygen species (ROS), which leads to the defects in barrier integrity. Together, our results establish that BRG1 may represent an autophagy checkpoint that is pathogenetically linked to colitis and is therefore likely a potential therapeutic target for disease intervention. |
| 学科主题 | Chemistry |
| WOS关键词 | ULCERATIVE-COLITIS ; CROHN-DISEASE ; PANETH CELLS ; CANCER ; PROMOTES ; SWI/SNF ; GENE ; HOMEOSTASIS ; IMMUNITY ; VARIANTS |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31601814 |
| WOS记录号 | WOS:000489557800007 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1214]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, State Key Lab Oncogenes & Related Genes, Renji Med X Clin Stem Cell Res Ctr, Ren Ji Hosp,Sch Med, Shanghai, Peoples R China; 2.Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai, Peoples R China; 3.Shanghai Jiao Tong Univ, Med X Res Inst, Shanghai, Peoples R China; 4.Univ Chinese Acad Sci, Chinese Acad Sci, CAS Key Lab Tissue Microenvironm & Tumor,Shanghai, CAS Ctr Excellence Mol Cell Sci,Shanghai Inst Nut, Shanghai, Peoples R China; 5.Fudan Univ, Shanghai Canc Ctr, Dept Colorectal Surg, Shanghai, Peoples R China; 6.Tongji Univ, Sch Med, Cent Lab Med Res, Shanghai Peoples Hosp 10, Shanghai, Peoples R China; 7.Chinese Acad Sci, Inst Zool, State Key Lab Stem Cell & Reprod Biol, Beijing, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Liu, Min,Li, Li,Gao, Wei-Qiang,et al. BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration[J]. NATURE COMMUNICATIONS,2019,10(-):4614. |
| APA | Liu, Min.,Li, Li.,Gao, Wei-Qiang.,Sun, Tongyu.,Li, Ni.,...&,.(2019).BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration.NATURE COMMUNICATIONS,10(-),4614. |
| MLA | Liu, Min,et al."BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration".NATURE COMMUNICATIONS 10.-(2019):4614. |
入库方式： OAI收割
来源：上海营养与健康研究所
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