Identifying Methylation Pattern and Genes Associated with Breast Cancer Subtypes
文献类型：期刊论文
| 作者 | Chen, Lei1,2,3; Cai, Yu-Dong2; Zeng, Tao4; Pan, Xiaoyong5,6,7; Zhang, Yu-Hang8; Huang, Tao8; , |
| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
 |
| 出版日期 | 2019 |
| 卷号 | 20期号:17页码:4269 |
| 关键词 | breast cancer subtype methylation pattern multi-class classification |
| ISSN号 | 1552-4450 |
| DOI | 10.3390/ijms20174269 |
| 文献子类 | Article |
| 英文摘要 | Breast cancer is regarded worldwide as a severe human disease. Various genetic variations, including hereditary and somatic mutations, contribute to the initiation and progression of this disease. The diagnostic parameters of breast cancer are not limited to the conventional protein content and can include newly discovered genetic variants and even genetic modification patterns such as methylation and microRNA. In addition, breast cancer detection extends to detailed breast cancer stratifications to provide subtype-specific indications for further personalized treatment. One genome-wide expression-methylation quantitative trait loci analysis confirmed that different breast cancer subtypes have various methylation patterns. However, recognizing clinically applied (methylation) biomarkers is difficult due to the large number of differentially methylated genes. In this study, we attempted to re-screen a small group of functional biomarkers for the identification and distinction of different breast cancer subtypes with advanced machine learning methods. The findings may contribute to biomarker identification for different breast cancer subtypes and provide a new perspective for differential pathogenesis in breast cancer subtypes. |
| 学科主题 | Biochemistry & Molecular Biology |
| WOS关键词 | EPIGENETIC MODIFICATIONS ; EXPRESSION SIGNATURE ; DNA METHYLATION ; CELL-LINES ; IDENTIFICATION ; RISK ; METASTASIS ; WOMEN ; PREDICTION ; BIOMARKERS |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31480430 |
| WOS记录号 | WOS:000486888400201 |
| 出版者 | MDPI |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1221]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Maritime Univ, Coll Informat Engn, Shanghai 201306, Peoples R China; 2.Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China; 3.East China Normal Univ, Shanghai Key Lab PMMP, Shanghai 200241, Peoples R China; 4.Chinese Acad Sci, Key Lab Syst Biol, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China; 5.Shanghai Jiao Tong Univ, Inst Image Proc & Pattern Recognit, Shanghai 200240, Peoples R China; 6.Minist Educ China, Key Lab Syst Control & Informat Proc, Shanghai 200240, Peoples R China; 7.Univ Ghent, IDLab, Dept Elect & Informat Syst, B-9000 Ghent, Belgium; 8.Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Chen, Lei,Cai, Yu-Dong,Zeng, Tao,et al. Identifying Methylation Pattern and Genes Associated with Breast Cancer Subtypes[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2019,20(17):4269. |
| APA | Chen, Lei.,Cai, Yu-Dong.,Zeng, Tao.,Pan, Xiaoyong.,Zhang, Yu-Hang.,...&,.(2019).Identifying Methylation Pattern and Genes Associated with Breast Cancer Subtypes.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,20(17),4269. |
| MLA | Chen, Lei,et al."Identifying Methylation Pattern and Genes Associated with Breast Cancer Subtypes".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 20.17(2019):4269. |
入库方式： OAI收割
来源：上海营养与健康研究所
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