Niacin ameliorates ulcerative colitis via prostaglandin D-2-mediated D prostanoid receptor 1 activation
文献类型：期刊论文
| 作者 | Li, Juanjuan9,10; Wang, Qi10; Wu, Wei10; Tang, Yanping10; Bai, Tingting10; Wei, Lumin9,10; Qian, Yuting10; Wu, Sheng10; Zang, Yi10; Yao, Weiyan10 |
| 刊名 | EMBO MOLECULAR MEDICINE
 |
| 出版日期 | 2017 |
| 卷号 | 9期号:5页码:571-588 |
| 关键词 | DP1 receptor niacin prostaglandin retention enema ulcerative colitis |
| ISSN号 | 1757-4676 |
| DOI | 10.15252/emmm.201606987 |
| 文献子类 | Article |
| 英文摘要 | Niacin, as an antidyslipidemic drug, elicits a strong flushing response by release of prostaglandin (PG) D-2. However, whether niacin is beneficial for inflammatory bowel disease (IBD) remains unclear. Here, we observed niacin administration-enhanced PGD(2) production in colon tissues in dextran sulfate sodium (DSS)-challenged mice, and protected mice against DSS or 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in D prostanoid receptor 1 (DP1)-dependent manner. Specific ablation of DP1 receptor in vascular endothelial cells, colonic epithelium, and myeloid cells augmented DSS/TNBS-induced colitis in mice through increasing vascular permeability, promoting apoptosis of epithelial cells, and stimulating pro-inflammatory cytokine secretion of macrophages, respectively. Niacin treatment improved vascular permeability, reduced apoptotic epithelial cells, promoted epithelial cell update, and suppressed pro-inflammatory gene expression of macrophages. Moreover, treatment with niacin-containing retention enema effectively promoted UC clinical remission and mucosal healing in patients with moderately active disease. Therefore, niacin displayed multiple beneficial effects on DSS/TNBS-induced colitis in mice by activation of PGD(2)/DP1 axis. The potential efficacy of niacin in management of IBD warrants further investigation. |
| 学科主题 | Research & Experimental Medicine |
| WOS关键词 | INFLAMMATORY-BOWEL-DISEASE ; EXTENDED-RELEASE NIACIN ; NICOTINIC-ACID ; CARDIOVASCULAR-DISEASE ; DEPENDENT MECHANISMS ; LANGERHANS CELLS ; MURINE COLITIS ; IBD PATIENTS ; OLD DRUG ; D-2 |
| 语种 | 英语 |
| WOS记录号 | WOS:000400347200003 |
| 出版者 | WILEY |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1226]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Tianjin Med Univ, Sch Basic Med Sci, Dept Pharmacol, Tianjin, Peoples R China; 2.Vanderbilt Univ, Med Ctr, Dept Med, 221 Kirkland Hall, Nashville, TN 37235 USA, 3.Tennessee Valley Hlth Author, Dept Vet Affairs, Nashville, TN USA; 4.Univ Tsukuba, Int Inst Integrat Sleep Med WPI IIIS, Tsukuba, Ibaraki, Japan; 5.Tokyo Med & Dent Univ, Human Gene Sci Ctr, Bunkyo Ku, Tokyo, Japan; 6.Nanjing Med Univ, Atherosclerosis Res Ctr, Key Lab Cardiovasc Dis & Mol Intervent, Nanjing, Jiangsu, Peoples R China; 7.Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China; 8.Fudan Univ, Shanghai Canc Ctr, Breast Canc Inst, Dept Breast Surg, Shanghai, Peoples R China; 9.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab food safety Res, Shanghai, Peoples R China; 10.Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Gastroenterol, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li, Juanjuan,Wang, Qi,Wu, Wei,et al. Niacin ameliorates ulcerative colitis via prostaglandin D-2-mediated D prostanoid receptor 1 activation[J]. EMBO MOLECULAR MEDICINE,2017,9(5):571-588. |
| APA | Li, Juanjuan.,Wang, Qi.,Wu, Wei.,Tang, Yanping.,Bai, Tingting.,...&,.(2017).Niacin ameliorates ulcerative colitis via prostaglandin D-2-mediated D prostanoid receptor 1 activation.EMBO MOLECULAR MEDICINE,9(5),571-588. |
| MLA | Li, Juanjuan,et al."Niacin ameliorates ulcerative colitis via prostaglandin D-2-mediated D prostanoid receptor 1 activation".EMBO MOLECULAR MEDICINE 9.5(2017):571-588. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。