Nanodiamonds Interfere with Wnt-Regulated Cell Migration and Adipocyte Differentiation in Cells and Embryonic Development In Vivo
文献类型：期刊论文
| 作者 | Yi, Hongyang2,3,5; Li, Xiaojiao2,5; Wang, Zhuyao2,5; Wang, Hui2,5; Song, Haiyun2,5; Chen, Luonan3; Yin, Min1,6; Wang, Lihua1,6; Chen, Nan1,6; Fan, Chunhai1,6 |
| 刊名 | PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
 |
| 出版日期 | 2017 |
| 卷号 | 34期号:1页码:1600208 |
| 关键词 | cancer cell migration embryonic development nanodiamonds obesity signal transduction |
| ISSN号 | 0934-0866 |
| DOI | 10.1002/ppsc.201600208 |
| 文献子类 | Article |
| 英文摘要 | Biocompatible nanoparticles hold a great promise for biomedical applications, whereas their biosafety has raised extensive concerns. Nanodiamonds (NDs) are generally regarded as inert nanocarriers and widely employed in biomedical studies; however, it is yet to explore their biological effects in more general contexts. In this study, the authors observe that intracellular NDs block signal transduction of the Wnt signaling pathway, an effect that is not caused by general cytotoxicity. The authors find that NDs attenuate activities of Wnt signaling in several types of cell lines and in Zebrafish, and interfere with Wnt signaling-controlled biological processes, including cancer cell migration, adipocyte differentiation, and embryonic development. Significantly, the authors show that intracellular NDs trigger degradation of the disheveled protein, a key component of Wnt signaling cascade, while they do not affect protein stability of other Wnt signal transducers or other signaling molecules. This work thus illustrates a novel crosstalk between nanoparticles and the Wnt signaling pathway, and expands the understanding of biological effects induced by nanoparticles. In addition, given the clinical implications of Wnt signaling in tumorigenesis and cancer metastasis, this study also provides the rationale for potential applications of NDs in cancer therapies. |
| 学科主题 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| WOS关键词 | IRON-OXIDE NANOPARTICLES ; GOLD NANOPARTICLES ; FLUORESCENT NANODIAMONDS ; CAENORHABDITIS-ELEGANS ; DRUG-DELIVERY ; CATENIN ; BIOCOMPATIBILITY ; PHOSPHORYLATION ; ADIPOGENESIS ; DEGRADATION |
| 语种 | 英语 |
| WOS记录号 | WOS:000393580600007 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1227]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Div Phys Biol, Shanghai 201800, Peoples R China; 2.Minist Hlth, Key Lab food safety risk Assessment, Beijing 100021, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Syst Biol, Shanghai 200031, Peoples R China; 4.King Saud Univ, Dept Chem, Riyadh 11451, Saudi Arabia, 5.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab food safety Res,Inst Nutr Sci, Shanghai 200031, Peoples R China; 6.Chinese Acad Sci, CAS Key Lab Interfacial Phys & Technol, Shanghai Synchrotron Radiat Facil, Shanghai Inst Appl Phys,Bioimaging Ctr, Shanghai 201800, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Yi, Hongyang,Li, Xiaojiao,Wang, Zhuyao,et al. Nanodiamonds Interfere with Wnt-Regulated Cell Migration and Adipocyte Differentiation in Cells and Embryonic Development In Vivo[J]. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,2017,34(1):1600208. |
| APA | Yi, Hongyang.,Li, Xiaojiao.,Wang, Zhuyao.,Wang, Hui.,Song, Haiyun.,...&,.(2017).Nanodiamonds Interfere with Wnt-Regulated Cell Migration and Adipocyte Differentiation in Cells and Embryonic Development In Vivo.PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,34(1),1600208. |
| MLA | Yi, Hongyang,et al."Nanodiamonds Interfere with Wnt-Regulated Cell Migration and Adipocyte Differentiation in Cells and Embryonic Development In Vivo".PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION 34.1(2017):1600208. |
入库方式： OAI收割
来源：上海营养与健康研究所
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