中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海营养与健康研究所
  3. 中国科学院上海生命科学研究院营养科学研究所
Niacin Promotes Cardiac Healing after Myocardial Infarction through Activation of the Myeloid Prostaglandin D-2 Receptor Subtype 1

文献类型：期刊论文

作者Kong, Deping4,5; Shen, Yujun4; Yu, Ying4,5; Liu, Guizhu5; Zuo, Shengkai5; Tao, Bo5; Li, Juanjuan6; Lu, Ankang7; Ji, Yong8; Lazarus, Michael1
刊名JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
出版日期2017
卷号360期号:3页码:435-444
关键词Ebola virus pathogenic mechanism shortest path human protein identification betweenness GO enrichment
ISSN号0022-3565
DOI10.1124/jpet.116.238261
文献子类Article
英文摘要Niacin is a well established drug used to lower cholesterol and prevent cardiovascular disease events. However, niacin also causes cutaneous flushing side effects due to release of the proresolution mediator prostaglandin D-2 (PGD(2)). Recent randomized clinical trials have demonstrated that addition of niacin with laropiprant [a PGD2 receptor subtype 1 (DP1) blocker] to statin-based therapies does not significantly decrease the risk of cardiovascular disease events, but increases the risk of serious adverse events. Here, we tested whether, and how, niacin beneficial effects on myocardial ischemia require the activation of the PGD(2)/DP1 axis. Myocardial infarction (MI) was reproduced by ligation of the left anterior descending branch of the coronary artery in mice. We found that niacin increased PGD(2) release in macrophages and shifted macrophages to M2 polarization both in vitro and in vivo by activation of DP1 and accelerated inflammation resolution in zymosan-induced peritonitis in mice. Moreover, niacin treatment facilitated wound healing and improved cardiac function after MI through DP1-mediated M2 bias and timely resolution of inflammation in infarcted hearts. In addition, we found that niacin intake also stimulated M2 polarization of peripheral monocytes in humans. Collectively, niacin promoted cardiac functional recovery after ischemic myocardial infarction through DP1-mediated M2 polarization and timely resolution of inflammation in hearts. These results indicated that DP1 inhibition may attenuate the cardiovascular benefits of niacin.
学科主题Pharmacology & Pharmacy
WOS关键词NICOTINIC-ACID ; MOLECULAR-IDENTIFICATION ; ALLERGIC INFLAMMATION ; D SYNTHASE ; IN-VITRO ; PGD(2) ; CELLS ; MICE ; BIOSYNTHESIS ; HUMANS
语种英语
WOS记录号WOS:000394539900007
出版者AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
版本出版稿
源URL[http://202.127.25.144/handle/331004/1228]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Univ Tsukuba, Int Inst Integrat, Sleep Med, Tsukuba, Ibaraki, Japan;
2.Vanderbilt Univ, Med Ctr, Dept Vet Affairs, Tennessee Valley Hlth Author, Nashville, TN USA;
3.Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USA,
4.Tianjin Med Univ, Sch Basic Med Sci, Dept Pharmacol, Tianjin 300070, Peoples R China;
5.Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab food safety Res, Shanghai, Peoples R China;
6.Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Gastroenterol, Shanghai, Peoples R China;
7.Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Cardiol, Shanghai, Peoples R China;
8.Nanjing Med Univ, Atherosclerosis Res Ctr, Key Lab Cardiovasc Dis & Mol Intervent, Nanjing, Jiangsu, Peoples R China;
推荐引用方式
GB/T 7714		 Kong, Deping,Shen, Yujun,Yu, Ying,et al. Niacin Promotes Cardiac Healing after Myocardial Infarction through Activation of the Myeloid Prostaglandin D-2 Receptor Subtype 1[J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS,2017,360(3):435-444.
APA Kong, Deping.,Shen, Yujun.,Yu, Ying.,Liu, Guizhu.,Zuo, Shengkai.,...&,.(2017).Niacin Promotes Cardiac Healing after Myocardial Infarction through Activation of the Myeloid Prostaglandin D-2 Receptor Subtype 1.JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS,360(3),435-444.
MLA Kong, Deping,et al."Niacin Promotes Cardiac Healing after Myocardial Infarction through Activation of the Myeloid Prostaglandin D-2 Receptor Subtype 1".JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 360.3(2017):435-444.

入库方式： OAI收割

来源：上海营养与健康研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。