MicroRNA-4639 Is a Regulator of DJ-1 Expression and a Potential Early Diagnostic Marker for Parkinson's Disease
文献类型：期刊论文
| 作者 | Chen, Yimeng1,2,3,4; Pan, Hong1,2,3,4; Chen, Shengdi1,2,3,4; Gao, Chao2,3; Sun, Qian2,3; Huang, Pei2,3; Ding, Jianqing2,3; Gao, Chao5,6; , |
| 刊名 | FRONTIERS IN AGING NEUROSCIENCE
 |
| 出版日期 | 2017 |
| 卷号 | 9期号:-页码:232 |
| ISSN号 | 1663-4365 |
| 关键词 | Parkinson's disease hsa-miR-4639-5p plasma biomarker DJ-1 oxidative stress |
| DOI | 10.3389/fnagi.2017.00232 |
| 文献子类 | Article |
| 英文摘要 | Parkinson's disease (PD) is the second most common neurodegenerative disorder and has profound impacts on the daily lives of patients. However, there is a lack of effective biomarkers for early diagnosis, and the mechanisms of PD pathogenesis remain obscure. microRNAs (miRNAs) are post-transcriptional gene regulators and can be easily detected in plasma, which suggests a promising role as diagnostic markers. Here, we aimed to explore a peripheral biomarker, which not only can be applied for early diagnosis of PD but also has the potential to be a therapeutic target. Through miRNA microarray screening and further validation in plasma from 169 sporadic PD patients, 170 healthy controls, and 60 essential tremor (ET) patients, hsa-miR-4639-5p level was identified to be significantly up-regulated in PD patients. Also, it was able to discriminate between early PD patients (disease duration <= 2 years or Hoehn and Yahr stage 1-2.5) and healthy controls. Furthermore, hsa-miR-4639-5p was shown to negatively regulate DJ-1 (PARK7), a well-known PD-related gene, in the post-transcriptional level. Abnormal up-regulation of hsa-miR-4639-5p caused down-regulation of DJ-1 protein level, leading to severe oxidative stress and neuronal death. In conclusion, hsa-miR4639- 5p has the potential to be a peripheral diagnostic biomarker and therapeutic target for early PD. |
| 学科主题 | Geriatrics & Gerontology ; Neurosciences & Neurology |
| WOS关键词 | CLINICAL-DIAGNOSIS ; GENE ; NEURODEGENERATION ; PROGRESSION ; IMPAIRMENT ; BIOMARKERS ; COMPLEX ; IMPACT ; CANCER |
| 语种 | 英语 |
| 出版者 | FRONTIERS MEDIA SA |
| WOS记录号 | WOS:000406188500001 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1230]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Lab Neurodegenerat Dis,Inst Hlth Sci, Shanghai, Peoples R China; 2.Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Neurol, Shanghai, Peoples R China; 3.Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Inst Neurol, Shanghai, Peoples R China; 4.Shanghai Jiao Tong Univ, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Stem Cell Biol,Inst Hlth Sci,Sch Med, Shanghai, Peoples R China; 5.Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai, Peoples R China; 6.Shanghai Jiao Tong Univ, Med Res Inst X, Shanghai, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Chen, Yimeng,Pan, Hong,Chen, Shengdi,et al. MicroRNA-4639 Is a Regulator of DJ-1 Expression and a Potential Early Diagnostic Marker for Parkinson's Disease[J]. FRONTIERS IN AGING NEUROSCIENCE,2017,9(-):232. |
| APA | Chen, Yimeng.,Pan, Hong.,Chen, Shengdi.,Gao, Chao.,Sun, Qian.,...&,.(2017).MicroRNA-4639 Is a Regulator of DJ-1 Expression and a Potential Early Diagnostic Marker for Parkinson's Disease.FRONTIERS IN AGING NEUROSCIENCE,9(-),232. |
| MLA | Chen, Yimeng,et al."MicroRNA-4639 Is a Regulator of DJ-1 Expression and a Potential Early Diagnostic Marker for Parkinson's Disease".FRONTIERS IN AGING NEUROSCIENCE 9.-(2017):232. |
入库方式： OAI收割
来源：上海营养与健康研究所
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