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Development and Application of Base Editors

文献类型：期刊论文

作者Yang, Bei1; Yang, Li2,3; Chen, Jia3; Chen, Jia4; ,
刊名CRISPR JOURNAL
出版日期2019
卷号2期号:2页码:91-104
关键词GBM glioma proteomics analysis gene expression analysis Bioinformatics Analysis
ISSN号2573-1599
DOI10.1089/crispr.2019.0001
文献子类Review
英文摘要Base editing is emerging as a potent new strategy to achieve precise gene editing. By combining different nucleobase deaminases with Cas9 or Cpf1 proteins, several base editors have recently been developed to achieve targeted base conversions in different genomic contexts. Importantly, base editors have been successfully applied in animals, plants, and bacteria to induce precise substitutions at the single-base level with high efficiency. In this review, we summarize recent progress in the development and application of base editors and discuss some of the future directions of the technology.
学科主题Oncology ; Cell Biology
WOS关键词CYTOSINE DEAMINATION ; DIRECTED EVOLUTION ; DNA-POLYMERASES ; HUMAN CANCERS ; GENOMIC DNA ; CRISPR ; REPAIR ; STRAND ; PATHWAY ; APOBEC
语种英语
CSCD记录号CSCD:30998092
WOS记录号WOS:000466792400008
出版者MARY ANN LIEBERT, INC
版本出版稿
源URL[http://202.127.25.144/handle/331004/1232]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China;
2.ShanghaiTech Univ, Sch Life Sci & Technol, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China;
3.Chinese Acad Sci, CAS Key Lab Computat Biol, CAS Max Planck Gesell Partner Inst Computat Biol, Shanghai Inst Nutr & Hlth,Shanghai Inst Biol Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China;
4.Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol, Shanghai, Peoples R China,
推荐引用方式
GB/T 7714		 Yang, Bei,Yang, Li,Chen, Jia,et al. Development and Application of Base Editors[J]. CRISPR JOURNAL,2019,2(2):91-104.
APA Yang, Bei,Yang, Li,Chen, Jia,Chen, Jia,&,.(2019).Development and Application of Base Editors.CRISPR JOURNAL,2(2),91-104.
MLA Yang, Bei,et al."Development and Application of Base Editors".CRISPR JOURNAL 2.2(2019):91-104.

入库方式： OAI收割

来源：上海营养与健康研究所

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