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IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-Dependent Anti-inflammatory Properties

文献类型：期刊论文

作者Du, Liming1,2,3,4; Lin, Liangyu1,2,3,4; Li, Qing2,3; Liu, Keli2,3; Huang, Yin2,3; Wang, Xuefeng2,3; Cao, Kai2,3; Chen, Xiaodong2,3; Cao, Wei2,3; Li, Fengying2,3
刊名CELL METABOLISM
出版日期2019
卷号29期号:6页码:1363+
ISSN号1550-4131
DOI10.1016/j.cmet.2019.01.006
文献子类Article
英文摘要Recent investigations revealed that macrophages could be trained with an altered responsiveness, raising the possibility of combating autoimmune diseases by imparting anti-inflammatory capabilities to these cells. While investigating the effect of mesenchymal stem cells on experimental autoimmune encephalomyelitis (EAE), we found a critical role of insulin-like growth factor 2 (IGF-2) in training macrophages to become anti-inflammatory during their maturation. IGF-2 exerts its effects by preprogramming maturing macrophages to commit oxidative phosphorylation (OXPHOS). IGF-2-preprogrammed macrophages maintained the mitochondrial complex V activities even upon pro-inflammation stimulation, thus enabling an elevated programmed death-ligand 1 (PD-L1) expression. PD-L1 neutralization abolished the beneficial effect of IGF-2 on EAE. Furthermore, adoptive transfer of IGF-2-preprogrammed macrophages to EAE mice increased Tregs and alleviated the diseases. Our results demonstrate that shaping macrophage responsiveness by IGF-2 is effective in managing inflammatory diseases, and the OXPHOS commitment can be preset to determine the anti-inflammatory fate of macrophages.
学科主题Science & Technology - Other Topics
WOS关键词MESENCHYMAL STEM-CELLS ; GROWTH-FACTOR-I ; MEDIATED IMMUNOSUPPRESSION ; TRAINED IMMUNITY ; ADIPOSE TISSUE ; INSULIN ; IMMUNOMETABOLISM ; INFLAMMATION ; ACTIVATION ; EXPRESSION
语种英语
CSCD记录号CSCD:30745181
WOS记录号WOS:000470097200013
出版者CELL PRESS
版本出版稿
源URL[http://202.127.25.144/handle/331004/1237]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Soochow Univ, State Key Lab Radiat Med & Protect, Inst Translat Med, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China,
2.Shanghai Jiao Tong Univ, Sch Med, Shanghai 200025, Peoples R China;
3.Chinese Acad Sci, Key Lab Tissue Microenvironm & Tumor, Shanghai Inst Biol Sci, Shanghai 200025, Peoples R China;
4.Soochow Univ, Affiliated Hosp 1, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China;
推荐引用方式
GB/T 7714		 Du, Liming,Lin, Liangyu,Li, Qing,et al. IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-Dependent Anti-inflammatory Properties[J]. CELL METABOLISM,2019,29(6):1363+.
APA Du, Liming.,Lin, Liangyu.,Li, Qing.,Liu, Keli.,Huang, Yin.,...&,.(2019).IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-Dependent Anti-inflammatory Properties.CELL METABOLISM,29(6),1363+.
MLA Du, Liming,et al."IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-Dependent Anti-inflammatory Properties".CELL METABOLISM 29.6(2019):1363+.

入库方式： OAI收割

来源：上海营养与健康研究所

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