Response to Comment on Adam et al. Metformin Effect on Nontargeted Metabolite Profiles in Patients With Type 2 Diabetes and in Multiple Murine Tissues. Diabetes 2016;65:3776-3785
文献类型：期刊论文
| 作者 | Adam, Jonathan3,4,5; Brandmaier, Stefan3,4,5; Troll, Martina3,4,5; Rotter, Markus3,4,5; Wang-Sattler, Rui3,4,5; Heier, Margit4; Adamski, Jerzy5; Neschen, Susanne5,7; Kastenmueller, Gabi5; Mohney, Robert P.2 |
| 刊名 | DIABETES
 |
| 出版日期 | 2017 |
| 卷号 | 66期号:5页码:e3-e4 |
| ISSN号 | 0012-1797 |
| DOI | 10.2337/dbi17-0010 |
| 文献子类 | Letter |
| 英文摘要 | Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk globally. Large-scale schizophrenia genetic studies have reported primarily on European ancestry samples, potentially missing important biological insights. Here, we report the largest study to date of East Asian participants (22,778 schizophrenia cases and 35,362 controls), identifying 21 genome-wide-significant associations in 19 genetic loci. Common genetic variants that confer risk for schizophrenia have highly similar effects between East Asian and European ancestries (genetic correlation = 0.98 +/- 0.03), indicating that the genetic basis of schizophrenia and its biology are broadly shared across populations. A fixed-effect meta-analysis including individuals from East Asian and European ancestries identified 208 significant associations in 176 genetic loci (53 novel). Trans-ancestry fine-mapping reduced the sets of candidate causal variants in 44 loci. Polygenic risk scores had reduced performance when transferred across ancestries, highlighting the importance of including sufficient samples of major ancestral groups to ensure their generalizability across populations. |
| 学科主题 | Endocrinology & Metabolism |
| WOS关键词 | GENOME-WIDE ASSOCIATION ; POLYGENIC RISK SCORES ; INFLAMMATORY-BOWEL-DISEASE ; 38 SUSCEPTIBILITY LOCI ; GENOTYPE IMPUTATION ; COMMON VARIANTS ; HAN CHINESE ; METAANALYSIS ; INDIVIDUALS ; SELECTION |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31740837 |
| WOS记录号 | WOS:000399799800002 |
| 出版者 | AMER DIABETES ASSOC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1244]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Educ City Qatar Fdn, WCMC Q, Dept Physiol & Biophys, Doha, Qatar; 2.Metabolon Inc, Durham, NC USA; 3.Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany; 4.Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany; 5.German Ctr Diabet Res DZD, Neuherberg, Germany; 6.Helmholtz Zentrum Munchen, Inst Expt Genet, Genome Anal Ctr, Neuherberg, Germany; 7.Helmholtz Zentrum Munchen, Inst Expt Genet, Neuherberg, Germany; 8.Tech Univ Munich, Inst Expt Genet, Ctr Life & Food Sci Weihenstephan, Freising Weihenstephan, Germany; 9.Chinese Acad Sci, CAS MPG Partner Inst Computat Biol, Shanghai Inst Biol Sci, Key Lab Computat Biol, Shanghai, Peoples R China; 10.Helmholtz Zentrum Munchen, Inst Bioinformat & Syst Biol, Neuherberg, Germany; |
| 推荐引用方式 GB/T 7714 | Adam, Jonathan,Brandmaier, Stefan,Troll, Martina,et al. Response to Comment on Adam et al. Metformin Effect on Nontargeted Metabolite Profiles in Patients With Type 2 Diabetes and in Multiple Murine Tissues. Diabetes 2016;65:3776-3785[J]. DIABETES,2017,66(5):e3-e4. |
| APA | Adam, Jonathan.,Brandmaier, Stefan.,Troll, Martina.,Rotter, Markus.,Wang-Sattler, Rui.,...&,.(2017).Response to Comment on Adam et al. Metformin Effect on Nontargeted Metabolite Profiles in Patients With Type 2 Diabetes and in Multiple Murine Tissues. Diabetes 2016;65:3776-3785.DIABETES,66(5),e3-e4. |
| MLA | Adam, Jonathan,et al."Response to Comment on Adam et al. Metformin Effect on Nontargeted Metabolite Profiles in Patients With Type 2 Diabetes and in Multiple Murine Tissues. Diabetes 2016;65:3776-3785".DIABETES 66.5(2017):e3-e4. |
入库方式： OAI收割
来源：上海营养与健康研究所
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