SF3B4 is decreased in pancreatic cancer and inhibits the growth and migration of cancer cells
文献类型：期刊论文
| 作者 | Zhou, Wentao1; Rong, Yefei1; Zhu, Hongxu1; Kuang, Tiantao1; Lou, Wenhui1; Wang, Dansong1; Ma, Ning2; Deng, Yuezhen2; Feng, Yuanyuan2; Xie, Dong2,3 |
| 刊名 | TUMOR BIOLOGY
 |
| 出版日期 | 2017 |
| 卷号 | 39期号:3页码:- |
| 关键词 | Splicing factor 3b subunit 4 pancreatic cancer signal transducer and activator of transcription 3 signaling cell proliferation cell migration |
| ISSN号 | 1010-4283 |
| DOI | 10.1177/1010428317695913 |
| 文献子类 | Article |
| 英文摘要 | Splicing factor 3b subunit 4, a critical component of pre-message RNA splicing complex, has been reported to play an important part in the tumorigenesis. However, the expression pattern and biological role of splicing factor 3b subunit 4 in pancreatic cancer have never been investigated. In this study, we found that both the messenger RNA (p < 0.001) and protein level of splicing factor 3b subunit 4 were decreased significantly in pancreatic cancer specimens compared with their adjacent normal tissues. Overexpression of splicing factor 3b subunit 4 in pancreatic cancer cells inhibited cell growth and motility in vitro, while suppressing splicing factor 3b subunit 4 expression promoted the proliferation and migration of pancreatic cancer cells. In addition, splicing factor 3b subunit 4 was found to inhibit the activity of signal transducer and activator of transcription 3 signaling via downregulating the phosphorylation of signal transducer and activator of transcription 3 on a tyrosine residue at position 705. Taken together, these findings demonstrated that splicing factor 3b subunit 4 acted as a suppressive role in pancreatic cancer and indicated that restoring the function of splicing factor 3b subunit 4 might be a strategy for cancer therapy. |
| 学科主题 | Oncology |
| WOS关键词 | HEPATOCELLULAR-CARCINOMA ; SIGNALING PATHWAY ; BREAST-CANCER ; STAT3 ; TRANSDUCER ; STATISTICS ; ACTIVATION ; EXPRESSION ; PROLIFERATION ; TUMORIGENESIS |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31537377 |
| WOS记录号 | WOS:000400263700081 |
| 出版者 | SAGE PUBLICATIONS LTD |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1253]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Fudan Univ, Zhongshan Hosp, Dept Gen Surg, 180 Fenglin Rd, Shanghai 200032, Peoples R China; 2.Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Lab Mol Oncol, 320 Yueyang Rd, Shanghai 200031, Peoples R China; 3.East China Univ Sci & Technol, Shanghai, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Zhou, Wentao,Rong, Yefei,Zhu, Hongxu,et al. SF3B4 is decreased in pancreatic cancer and inhibits the growth and migration of cancer cells[J]. TUMOR BIOLOGY,2017,39(3):-. |
| APA | Zhou, Wentao.,Rong, Yefei.,Zhu, Hongxu.,Kuang, Tiantao.,Lou, Wenhui.,...&,.(2017).SF3B4 is decreased in pancreatic cancer and inhibits the growth and migration of cancer cells.TUMOR BIOLOGY,39(3),-. |
| MLA | Zhou, Wentao,et al."SF3B4 is decreased in pancreatic cancer and inhibits the growth and migration of cancer cells".TUMOR BIOLOGY 39.3(2017):-. |
入库方式： OAI收割
来源：上海营养与健康研究所
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