SRSF1 Prevents DNA Damage and Promotes Tumorigenesis through Regulation of DBF4B Pre-mRNA Splicing
文献类型：期刊论文
| 作者 | Chen, Linlin1; Luo, Chunling1; Liu, Yuguo1; Wang, Qianqian1; Zhang, Chang1; Guo, Ruochen1; Zhang, Yanan1; Xie, Zhiqin1; Wei, Ning1; Feng, Ying1 |
| 刊名 | CELL REPORTS
 |
| 出版日期 | 2017 |
| 卷号 | 21期号:12页码:3406-3413 |
| 关键词 | Gastric cancer Malignant ascites Organoid Drug screening Personalised medicine |
| ISSN号 | 2211-1247 |
| DOI | 10.1016/j.celrep.2017.11.091 |
| 文献子类 | Article |
| 英文摘要 | Dysregulated alternative splicing events have been implicated in many types of cancer, but the underlying molecular mechanisms remain unclear. Here, we observe that the splicing factor SRSF1 regulates DBF4B exon6 splicing by specifically binding and promoting its inclusion. Knockdown of the exon6-containing isoform (DBF4B-FL) significantly inhibits the tumorigenic potential of colon cancer cells in vitro and in mice, and SRSF1 inactivation phenocopies DBF4B-FL depletion. DBF4B-FL and SRSF1 are required for cancer cell proliferation and for the maintenance of genomic stability. Overexpression of DBF4B-FL can protect against DNA damage induced by SRSF1 knockdown and rescues growth defects in SRSF1-depleted cells. Increased DBF4B exon6 inclusion parallels SRSF1 upregulation in clinical colorectal cancer samples. Taken together, our findings identify SRSF1 as a key regulator of DBF4B pre-mRNA splicing dysregulation in colon cancer, with possible clinical implications as candidate prognostic factors in cancer patients. |
| 学科主题 | Cell Biology |
| WOS关键词 | S-PHASE ; CANCER ; PROTEIN ; PROGRESSION ; IDENTIFICATION ; MECHANISMS ; APOPTOSIS ; REVEALS ; ASF/SF2 ; EVENTS |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31598791 |
| WOS记录号 | WOS:000418481600010 |
| 出版者 | CELL PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1268]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Chinese Acad Sci, Inst Nutr Sci,Key Lab food safety Res, Shanghai, Peoples R China; 2.Zhejiang Agr & Forestry Univ, State Key Lab Subtrop Silviculture, Hangzhou, Zhejiang, Peoples R China; 3.Fudan Univ, Zhongshan Hosp, Dept Gen Surg, Shanghai, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Chen, Linlin,Luo, Chunling,Liu, Yuguo,et al. SRSF1 Prevents DNA Damage and Promotes Tumorigenesis through Regulation of DBF4B Pre-mRNA Splicing[J]. CELL REPORTS,2017,21(12):3406-3413. |
| APA | Chen, Linlin.,Luo, Chunling.,Liu, Yuguo.,Wang, Qianqian.,Zhang, Chang.,...&,.(2017).SRSF1 Prevents DNA Damage and Promotes Tumorigenesis through Regulation of DBF4B Pre-mRNA Splicing.CELL REPORTS,21(12),3406-3413. |
| MLA | Chen, Linlin,et al."SRSF1 Prevents DNA Damage and Promotes Tumorigenesis through Regulation of DBF4B Pre-mRNA Splicing".CELL REPORTS 21.12(2017):3406-3413. |
入库方式： OAI收割
来源：上海营养与健康研究所
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