Study on the pathological mechanisms of heart failure by integrative analysis of transcriptomics and proteomics
文献类型：期刊论文
| 作者 | Zhang, Jian1; Wang, Yong1; Wang, Wei1; Wang, Yong2; Lin, Weili3; Zhu, Ruixin4; , |
| 刊名 | JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
 |
| 出版日期 | 2017 |
| 卷号 | 70期号:16页码:C62-C62 |
| ISSN号 | 0735-1097 |
| DOI | 10.1016/j.jacc.2017.07.212 |
| 文献子类 | Meeting Abstract |
| 英文摘要 | Alternative lengthening of telomeres (2ALT) is known to use homologous recombination (HR) to replicate telomeric DNA in a telomerase-independent manner. However, the detailed process remains largely undefined. It was reported that nuclear receptors COUP-TFII and TR4 are recruited to the enriched GGGTCA variant repeats embedded within ALT telomeres, implicating nuclear receptors in regulating ALT activity. Here, we identified a function of nuclear receptors in ALT telomere maintenance that involves a direct interaction between COUP-TFII/TR4 and FANCD2, the key protein in the Fanconi anemia (FA) DNA repair pathway. The COUP-TFII/TR4-FANCD2 complex actively induces the DNA damage response by recruiting endonuclease MUS81 and promoting the loading of the PCNA-POLD3 replication complex in ALT telomeres. Furthermore, the COUP-TFII/TR4-mediated ALT telomere pathway does not require the FA core complex or the monoubiquitylation of FANCD2, key steps in the canonical FA pathway. Thus, our findings reveal that COUP-TFII/TR4 regulates ALT telomere maintenance through a novel noncanonical FANCD2 pathway. |
| 学科主题 | Cardiovascular System & Cardiology |
| WOS关键词 | FANCONI-ANEMIA PATHWAY ; MONOUBIQUITINATED FANCD2 ; CROSS-LINKS ; INTERSTRAND ; TRANSCRIPTION ; INSTABILITY ; CHROMATIN ; GROWTH ; CANCER ; ORPHAN |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31633027 |
| WOS记录号 | WOS:000412550800208 |
| 出版者 | ELSEVIER SCIENCE INC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1270]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Beijing Univ Chinese Med, Basic Med Coll, Beijing, Peoples R China; 2.Beijing Univ Chinese Med, Sch Life Sci, Beijing, Peoples R China; 3.Chinese Acad Sci Shanghai, CAS MPG Partner Inst Computat Biol, Shanghai Inst Biol Sci, Key Lab Computat Biol, Shanghai, Peoples R China; 4.Tongji Univ, Sch Life Sci & Technol, Dept Bioinformat, Shanghai, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Zhang, Jian,Wang, Yong,Wang, Wei,et al. Study on the pathological mechanisms of heart failure by integrative analysis of transcriptomics and proteomics[J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY,2017,70(16):C62-C62. |
| APA | Zhang, Jian.,Wang, Yong.,Wang, Wei.,Wang, Yong.,Lin, Weili.,...&,.(2017).Study on the pathological mechanisms of heart failure by integrative analysis of transcriptomics and proteomics.JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY,70(16),C62-C62. |
| MLA | Zhang, Jian,et al."Study on the pathological mechanisms of heart failure by integrative analysis of transcriptomics and proteomics".JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 70.16(2017):C62-C62. |
入库方式： OAI收割
来源：上海营养与健康研究所
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