Systems analysis of cis-regulatory motifs in C-4 photosynthesis genes using maize and rice leaf transcriptomics data during a process of de-etiolation (vol 67, pg 5105, 2016)
文献类型：期刊论文
| 作者 | Xu, Jiajia1,2; Li, Yuanyuan1,2; Zhu, Xin-Guang1,2; Braeutigam, Andrea3; Weber, Andreas P. M.3; Li, Yuanyuan4; , |
| 刊名 | JOURNAL OF EXPERIMENTAL BOTANY
 |
| 出版日期 | 2017 |
| 卷号 | 68期号:11页码:3035-3035 |
| ISSN号 | 0022-0957 |
| DOI | 10.1093/jxb/erw461 |
| 文献子类 | Correction |
| 英文摘要 | Autism spectrum disorder (ASD) is a common neurodevelopmental disorder with yet incompletely uncovered molecular determinants. Alterations in the abundance of low molecular weight compounds (metabolites) in ASD could add to our understanding of the disease. Indeed, such alterations take place in the urine, plasma and cerebellum of ASD individuals. In this work, we investigated mass-spectrometric signal intensities of 1,366 metabolites in the prefrontal cortex grey matter of 32 ASD and 40 control individuals. 15% of these metabolites showed significantly different intensities in ASD and clustered in 16 metabolic pathways. Of them, ten pathways were altered in urine and blood of ASD individuals (Fisher test, p < 0.05), opening an opportunity for the design of new diagnostic instruments. Furthermore, metabolic measurements conducted in 40 chimpanzees and 40 macaques showed an excess of metabolite intensity differences unique to humans, supporting the hypothesized disruption of evolutionary novel cortical mechanisms in ASD. |
| 学科主题 | Plant Sciences |
| WOS关键词 | CHILDREN POPULATION ; SPECTRUM DISORDERS ; OXIDATIVE STRESS ; BIOMARKERS ; HERITABILITY ; GLUTATHIONE ; EVOLUTION ; PATHWAYS ; H-1-NMR ; PROFILE |
| 语种 | 英语 |
| WOS记录号 | WOS:000405579100033 |
| 出版者 | OXFORD UNIV PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1277]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, CAS Key Lab Computat Biol, Shanghai 200031, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, State Key Lab Hybrid Rice, Shanghai 200031, Peoples R China; 3.Heinrich Heine Univ, Inst Plant Biochem, Cluster Excellence Plant Sci CEPLAS, D-40225 Dusseldorf, Germany; 4.Heinrich Heine Univ, Plant Mol Physiol & Biotechnol Grp, Inst Dev & Mol Biol Plants, D-40225 Dusseldorf, Germany, |
| 推荐引用方式 GB/T 7714 | Xu, Jiajia,Li, Yuanyuan,Zhu, Xin-Guang,et al. Systems analysis of cis-regulatory motifs in C-4 photosynthesis genes using maize and rice leaf transcriptomics data during a process of de-etiolation (vol 67, pg 5105, 2016)[J]. JOURNAL OF EXPERIMENTAL BOTANY,2017,68(11):3035-3035. |
| APA | Xu, Jiajia.,Li, Yuanyuan.,Zhu, Xin-Guang.,Braeutigam, Andrea.,Weber, Andreas P. M..,...&,.(2017).Systems analysis of cis-regulatory motifs in C-4 photosynthesis genes using maize and rice leaf transcriptomics data during a process of de-etiolation (vol 67, pg 5105, 2016).JOURNAL OF EXPERIMENTAL BOTANY,68(11),3035-3035. |
| MLA | Xu, Jiajia,et al."Systems analysis of cis-regulatory motifs in C-4 photosynthesis genes using maize and rice leaf transcriptomics data during a process of de-etiolation (vol 67, pg 5105, 2016)".JOURNAL OF EXPERIMENTAL BOTANY 68.11(2017):3035-3035. |
入库方式： OAI收割
来源：上海营养与健康研究所
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