Autophagy inhibition prevents glucocorticoid-increased adiposity via suppressing BAT whitening
文献类型：期刊论文
| 作者 | Deng, Jiali2; Guo, Yajie2; Yuan, Feixiang2; Chen, Shanghai2; Yin, Hanrui2; Jiang, Xiaoxue2; Jiao, Fuxin2; Wang, Fenfen2; Ying, Hao2; Chen, Yan2 |
| 刊名 | AUTOPHAGY
 |
| 出版日期 | 2019 |
| 卷号 | 16期号:3页码:451-465 |
| ISSN号 | 1554-8627 |
| 关键词 | ATG7 autophagy BAT whitening BTG1 glucocorticoid |
| DOI | 10.1080/15548627.2019.1628537 |
| 文献子类 | Article |
| 英文摘要 | The mechanisms underlying glucocorticoid (GC)-increased adiposity are poorly understood. Brown adipose tissue (BAT) acquires white adipose tissue (WAT) cell features defined as BAT whitening under certain circumstances. The aim of our current study was to investigate the possibility and mechanisms of GC-induced BAT whitening. Here, we showed that one-week dexamethasone (Dex) treatment induced BAT whitening, characterized by lipid droplet accumulation, in vitro and in vivo. Furthermore, autophagy and ATG7 (autophagy related 7) expression was induced in BAT by Dex, and treatment with the autophagy inhibitor chloroquine or adenovirus-mediated ATG7 knockdown prevented Dex-induced BAT whitening and fat mass gain. Moreover, Dex-increased ATG7 expression and autophagy was mediated by enhanced expression of BTG1 (B cell translocation gene 1, anti-proliferative) that stimulated activity of CREB1 (cAMP response element binding protein 1). The importance of BTG1 in this regulation was further demonstrated by the observed BAT whitening in adipocyte-specific BTG1-overexpressing mice and the attenuated Dex-induced BAT whitening and fat mass gain in mice with BTG1 knockdown in BAT. Taken together, we showed that Dex induces a significant whitening of BAT via BTG1- and ATG7-dependent autophagy, which might contribute to Dex-increased adiposity. These results provide new insights into the mechanisms underlying GC-increased adiposity and possible strategy for preventing GC-induced side effects via the combined use of an autophagy inhibitor. |
| 学科主题 | Cell Biology |
| WOS关键词 | AMELIORATES LIVER STEATOSIS ; BROWN FAT ; OXIDATIVE STRESS ; BTG1 ; RECEPTOR ; MICE ; DIFFERENTIATION ; THERMOGENESIS ; ADIPOGENESIS ; ACTIVATION |
| 语种 | 英语 |
| 出版者 | TAYLOR & FRANCIS INC |
| WOS记录号 | WOS:000473099500001 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1295]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Chinese Acad Sci, State Key Lab Cell Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci,Chinese Acad Sci, Shanghai, Peoples R China; 2.Univ Chinese Acad Sci, CAS Key Lab Nutr Metab & Food Safety, Shanghai Inst Nutr & Hlth, Shanghai Inst Biol Sci,Chinese Acad Sci, Shanghai, Peoples R China; 3.Chinese Acad Sci, Key Lab Stem Cell Biol, Shanghai Inst Nutr & Hlth, Shanghai Inst Biol Sci, Shanghai, Peoples R China; 4.Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Deng, Jiali,Guo, Yajie,Yuan, Feixiang,et al. Autophagy inhibition prevents glucocorticoid-increased adiposity via suppressing BAT whitening[J]. AUTOPHAGY,2019,16(3):451-465. |
| APA | Deng, Jiali.,Guo, Yajie.,Yuan, Feixiang.,Chen, Shanghai.,Yin, Hanrui.,...&,.(2019).Autophagy inhibition prevents glucocorticoid-increased adiposity via suppressing BAT whitening.AUTOPHAGY,16(3),451-465. |
| MLA | Deng, Jiali,et al."Autophagy inhibition prevents glucocorticoid-increased adiposity via suppressing BAT whitening".AUTOPHAGY 16.3(2019):451-465. |
入库方式： OAI收割
来源：上海营养与健康研究所
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