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CHML promotes liver cancer metastasis by facilitating Rab14 recycle

文献类型：期刊论文

作者Chen, Tian-Wei2,3,4; Yin, Fen-Fen2,3; Yuan, Yan-Mei2,3; Guan, Dong-Xian2; Zhang, Erbin2,3; Zhang, Feng-Kun2,3; Jiang, Hao2,3; Ma, Ning2,3; Wang, Jing-Jing2; Ni, Qian-Zhi2,3
刊名NATURE COMMUNICATIONS
出版日期2019
卷号10期号:-页码:2510
ISSN号2041-1723
关键词Gene regulation immune response mouse model intestine
DOI10.1038/s41467-019-10364-0
文献子类Article
英文摘要Metastasis-associated recurrence is the major cause of poor prognosis in hepatocellular carcinoma (HCC), however, the underlying mechanisms remain largely elusive. In this study, we report that expression of choroideremia-like (CHML) is increased in HCC, associated with poor survival, early recurrence and more satellite nodules in HCC patients. CHML promotes migration, invasion and metastasis of HCC cells, in a Rab14-dependent manner. Mechanism study reveals that CHML facilitates constant recycling of Rab14 by escorting Rab14 to the membrane. Furthermore, we identify several metastasis regulators as cargoes carried by Rab14-positive vesicles, including Mucin13 and CD44, which may contribute to metastasis-promoting effects of CHML. Altogether, our data establish CHML as a potential promoter of HCC metastasis, and the CHML-Rab14 axis may be a promising therapeutic target for HCC.
学科主题Science & Technology - Other Topics
WOS关键词HEPATOCELLULAR-CARCINOMA ; PHAGOSOME MATURATION ; CELL-PROLIFERATION ; CHOROIDEREMIA ; COMPLEX ; GERANYLGERANYLATION ; PROTEINS ; GTPASES ; DISSOCIATION ; TRAFFICKING
语种英语
出版者NATURE PUBLISHING GROUP
WOS记录号WOS:000470656800018
版本出版稿
源URL[http://202.127.25.144/handle/331004/1304]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Hepat Surg 6, Changhai Rd 225, Shanghai 200438, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Nutr & Hlth, CAS Key Lab Nutr Metab & Food Safety, Xuhui Dist 200031, Peoples R China;
3.Chinese Acad Sci, Univ Chinese Acad Sci, Xuhui Dist 200031, Peoples R China;
4.Southern Med Univ, Fengxian Hosp, Dept Gen Surg, 6600 Nanfeng Rd, Shanghai 201499, Peoples R China;
5.Huzhou Univ, Peoples Hosp Affiliated 1, Dept Surg, Huzhou 313000, Peoples R China;
6.Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA;
7.Huzhou Univ, Peoples Hosp Affiliated 1, Key Lab Translat Med, Huzhou 313000, Peoples R China;
8.China Natl Ctr Food Safety Risk Assessment, NHC Key Lab Food Safety Risk Assessment, Beijing 100022, Peoples R China;
9.ShanghaiTech Univ, Sch Life Sci & Technol, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China,
推荐引用方式
GB/T 7714		 Chen, Tian-Wei,Yin, Fen-Fen,Yuan, Yan-Mei,et al. CHML promotes liver cancer metastasis by facilitating Rab14 recycle[J]. NATURE COMMUNICATIONS,2019,10(-):2510.
APA Chen, Tian-Wei.,Yin, Fen-Fen.,Yuan, Yan-Mei.,Guan, Dong-Xian.,Zhang, Erbin.,...&,.(2019).CHML promotes liver cancer metastasis by facilitating Rab14 recycle.NATURE COMMUNICATIONS,10(-),2510.
MLA Chen, Tian-Wei,et al."CHML promotes liver cancer metastasis by facilitating Rab14 recycle".NATURE COMMUNICATIONS 10.-(2019):2510.

入库方式： OAI收割

来源：上海营养与健康研究所

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