CHML promotes liver cancer metastasis by facilitating Rab14 recycle
文献类型:期刊论文
作者 | Chen, Tian-Wei2,3,4; Yin, Fen-Fen2,3; Yuan, Yan-Mei2,3; Guan, Dong-Xian2; Zhang, Erbin2,3; Zhang, Feng-Kun2,3; Jiang, Hao2,3; Ma, Ning2,3; Wang, Jing-Jing2; Ni, Qian-Zhi2,3 |
刊名 | NATURE COMMUNICATIONS
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出版日期 | 2019 |
卷号 | 10期号:-页码:2510 |
关键词 | Gene regulation immune response mouse model intestine |
ISSN号 | 2041-1723 |
DOI | 10.1038/s41467-019-10364-0 |
文献子类 | Article |
英文摘要 | Metastasis-associated recurrence is the major cause of poor prognosis in hepatocellular carcinoma (HCC), however, the underlying mechanisms remain largely elusive. In this study, we report that expression of choroideremia-like (CHML) is increased in HCC, associated with poor survival, early recurrence and more satellite nodules in HCC patients. CHML promotes migration, invasion and metastasis of HCC cells, in a Rab14-dependent manner. Mechanism study reveals that CHML facilitates constant recycling of Rab14 by escorting Rab14 to the membrane. Furthermore, we identify several metastasis regulators as cargoes carried by Rab14-positive vesicles, including Mucin13 and CD44, which may contribute to metastasis-promoting effects of CHML. Altogether, our data establish CHML as a potential promoter of HCC metastasis, and the CHML-Rab14 axis may be a promising therapeutic target for HCC. |
学科主题 | Science & Technology - Other Topics |
WOS关键词 | HEPATOCELLULAR-CARCINOMA ; PHAGOSOME MATURATION ; CELL-PROLIFERATION ; CHOROIDEREMIA ; COMPLEX ; GERANYLGERANYLATION ; PROTEINS ; GTPASES ; DISSOCIATION ; TRAFFICKING |
语种 | 英语 |
WOS记录号 | WOS:000470656800018 |
出版者 | NATURE PUBLISHING GROUP |
版本 | 出版稿 |
源URL | [http://202.127.25.144/handle/331004/1304] ![]() |
专题 | 中国科学院上海生命科学研究院营养科学研究所 |
作者单位 | 1.Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Hepat Surg 6, Changhai Rd 225, Shanghai 200438, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Nutr & Hlth, CAS Key Lab Nutr Metab & Food Safety, Xuhui Dist 200031, Peoples R China; 3.Chinese Acad Sci, Univ Chinese Acad Sci, Xuhui Dist 200031, Peoples R China; 4.Southern Med Univ, Fengxian Hosp, Dept Gen Surg, 6600 Nanfeng Rd, Shanghai 201499, Peoples R China; 5.Huzhou Univ, Peoples Hosp Affiliated 1, Dept Surg, Huzhou 313000, Peoples R China; 6.Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA; 7.Huzhou Univ, Peoples Hosp Affiliated 1, Key Lab Translat Med, Huzhou 313000, Peoples R China; 8.China Natl Ctr Food Safety Risk Assessment, NHC Key Lab Food Safety Risk Assessment, Beijing 100022, Peoples R China; 9.ShanghaiTech Univ, Sch Life Sci & Technol, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China, |
推荐引用方式 GB/T 7714 | Chen, Tian-Wei,Yin, Fen-Fen,Yuan, Yan-Mei,et al. CHML promotes liver cancer metastasis by facilitating Rab14 recycle[J]. NATURE COMMUNICATIONS,2019,10(-):2510. |
APA | Chen, Tian-Wei.,Yin, Fen-Fen.,Yuan, Yan-Mei.,Guan, Dong-Xian.,Zhang, Erbin.,...&,.(2019).CHML promotes liver cancer metastasis by facilitating Rab14 recycle.NATURE COMMUNICATIONS,10(-),2510. |
MLA | Chen, Tian-Wei,et al."CHML promotes liver cancer metastasis by facilitating Rab14 recycle".NATURE COMMUNICATIONS 10.-(2019):2510. |
入库方式: OAI收割
来源:上海营养与健康研究所
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