Gene expression differences among different MSI statuses in colorectal cancer
文献类型：期刊论文
| 作者 | Chen, Lei1,2; Wang, ShaoPeng1; Cai, Yu-Dong1; Pan, Xiaoyong3; Hu, XiaoHua4; Zhang, Yu-Hang5; Huang, Tao5; , |
| 刊名 | INTERNATIONAL JOURNAL OF CANCER
 |
| 出版日期 | 2018 |
| 卷号 | 143期号:7页码:1731-1740 |
| 关键词 | microsatellite instability colorectal cancer mRMR support vector machine |
| ISSN号 | 0020-7136 |
| DOI | 10.1002/ijc.31554 |
| 文献子类 | Article |
| 英文摘要 | Colorectal cancer is the third most common cancer in males and second in females. This disease can be caused by genetic and acquired/environmental factors. Microsatellite instability (MSI) is one of the major mechanisms in colorectal cancer. This mechanism is a specific condition of genetic hyper mutability that results from incompetent DNA mismatch repair. MSI has been applied to classify different colorectal cancer subtypes. However, the effects of MSI status on gene expression are largely unknown. In our study, we integrated the gene expression profile and MSI status of all CRC samples from the TCGA database, and then categorized the CRC samples into three subgroups, namely, MSI-stable, MSI-low, and MSI-high, according to the MSI status. We applied a novel computational method based on machine learning and screened the genes specifically expressed for the different colorectal cancer subtypes. The results showed the distinct mechanisms of the different colorectal cancer subtypes with MSI status and provided the genes that may be the optimal standards to further classify the various molecular subtypes of colorectal cancer with distinct MSI status. |
| 学科主题 | Oncology |
| WOS关键词 | MICROSATELLITE INSTABILITY ; MOLECULAR CHARACTERIZATION ; PROMOTER HYPERMETHYLATION ; MOLYBDENUM COFACTOR ; MUTUAL INFORMATION ; RECTAL-CANCER ; COLON-CANCER ; PROTEIN ; IDENTIFICATION ; RISK |
| 语种 | 英语 |
| WOS记录号 | WOS:000443392100019 |
| 出版者 | WILEY |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1307]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Univ, Coll Life Sci, Shanghai 200444, Peoples R China; 2.Shanghai Maritime Univ, Coll Informat Engn, Shanghai 201306, Peoples R China; 3.Erasmus MC, Dept Med Informat, Rotterdam, Netherlands; 4.Fudan Univ, Sch Life Sci, Dept Biostat & Computat Biol, Shanghai 200438, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 200031, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Chen, Lei,Wang, ShaoPeng,Cai, Yu-Dong,et al. Gene expression differences among different MSI statuses in colorectal cancer[J]. INTERNATIONAL JOURNAL OF CANCER,2018,143(7):1731-1740. |
| APA | Chen, Lei.,Wang, ShaoPeng.,Cai, Yu-Dong.,Pan, Xiaoyong.,Hu, XiaoHua.,...&,.(2018).Gene expression differences among different MSI statuses in colorectal cancer.INTERNATIONAL JOURNAL OF CANCER,143(7),1731-1740. |
| MLA | Chen, Lei,et al."Gene expression differences among different MSI statuses in colorectal cancer".INTERNATIONAL JOURNAL OF CANCER 143.7(2018):1731-1740. |
入库方式： OAI收割
来源：上海营养与健康研究所
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