A structurally guided dissection-then-evolution strategy for ligand optimization of smoothened receptor
文献类型：期刊论文
| 作者 | Ye, Lintao1,2,5,6; Ding, Kang1,5,6; Zhao, Fei1; Liu, Xiaoyan1; Wu, Yiran1; Liu, Yang1; Xue, Dongxiang1,2,5,6; Zhou, Fang1,2,5,6; Zhang, Xianjun1,5,6; Stevens, Raymond C.1,6 |
| 刊名 | MEDCHEMCOMM
 |
| 出版日期 | 2017 |
| 卷号 | 8期号:6页码:1332-1336 |
| ISSN号 | 2040-2503 |
| 关键词 | heavy metal contamination grain association mapping variation transporter Oryza sativa |
| DOI | 10.1039/c7md00104e |
| 文献子类 | Article |
| 英文摘要 | We present herein a novel dissection-then-evolution strategy for ligand optimization. Using the co-crystal structure of the smoothened receptor (SMO) as a guide, we studied the modular contribution of LY2940680 by systematically "silencing" the specific interaction between the individual residue(s) and the fragment in the ligand. Following evolution by focusing on the benzoyl part finally yielded an improved ligand 21. |
| 学科主题 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| WOS关键词 | BASAL-CELL CARCINOMA ; HEDGEHOG ; CANCER ; DISCOVERY ; DRUG ; ANTAGONISTS ; MODULATION ; RESISTANCE ; VISMODEGIB ; STABILITY |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| WOS记录号 | WOS:000404076200022 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1308]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.ShanghaiTech Univ, iHuman Inst, 2F Bldg 6,99 Haike Rd, Shanghai 201210, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, 555 Zuchongzhi Rd,Bldg 3,Room 426, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai 200031, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China; 5.Univ Chinese Acad Sci, 19A,Yuquan Rd, Beijing 100049, Peoples R China; 6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Ye, Lintao,Ding, Kang,Zhao, Fei,et al. A structurally guided dissection-then-evolution strategy for ligand optimization of smoothened receptor[J]. MEDCHEMCOMM,2017,8(6):1332-1336. |
| APA | Ye, Lintao.,Ding, Kang.,Zhao, Fei.,Liu, Xiaoyan.,Wu, Yiran.,...&,.(2017).A structurally guided dissection-then-evolution strategy for ligand optimization of smoothened receptor.MEDCHEMCOMM,8(6),1332-1336. |
| MLA | Ye, Lintao,et al."A structurally guided dissection-then-evolution strategy for ligand optimization of smoothened receptor".MEDCHEMCOMM 8.6(2017):1332-1336. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。