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A pilot study of new promising non-coding RNA diagnostic biomarkers for early-stage colorectal cancers

文献类型：期刊论文

作者Liu, Hanshao1,2,3; Chen, Aijun1; Tan, Dan1; Zhang, Wenpeng1; Wang, Mingliang1; Zhang, Xiaoren1,2,3; Ye, Deji3; Jiang, Wenxia3; ,
刊名CLINICAL CHEMISTRY AND LABORATORY MEDICINE
出版日期2019
卷号57期号:7页码:1073-1083
关键词biomarker colorectal cancer LncRNA plasma
ISSN号1434-6621
DOI10.1515/cclm-2019-0052
文献子类Article
英文摘要Background: Diagnostic biomarkers for the detection of colorectal cancers (CRCs) are lacking. Recent studies have demonstrated that circulating long non-coding RNAs have the potential to serve as biomarkers for the detection of cancers. We analyzed the significance of lncRNAs 91H, PVT-1 and MEG3 in the detection of CRC. Methods: We examined the expression levels of 13 candidate Inc RNAs in the plasma of 18 CRC patients and 20 non-cancerous controls. Then, we validated our findings by determining the expression levels of six promising lncRNAs in CRC tissues and normal colorectal tissues. Finally, we evaluated the clinical relevance of lncRNAs 91H, PVT-1 and MEG3 in the plasma of 58 CRC patients and 56 non-cancerous controls. Results: Our data revealed that the expression levels of lncRNAs 91H, PVT-1 and MEG3 were significantly higher in plasma samples from CRC patients than in those from non-cancerous controls. The combination of 91H, PVT-1 and MEG3 could discriminate CRC patients from noncancerous controls with an area under the receiver-operating curve (AUC) of 0.877 at a cut-off value of 0.3816, with a sensitivity of 82.76% and 78.57% specificity. More importantly, the combination of lncRNAs shows more sensitivity in the detection of early-stage CRC than the combination of CEA and CA19-9, biomarkers currently used for CRC detection (p <0.0001). Conclusions: lncRNAs 91H, PVT-1 and MEG3 are promising diagnostic biomarkers for early-stage CRC.
学科主题Medical Laboratory Technology
WOS关键词AFFECTS CELL-PROLIFERATION ; POOR-PROGNOSIS ; BREAST-CANCER ; POTENTIAL BIOMARKER ; TUMOR-MARKERS ; EXPRESSION ; GENE ; HOTAIR ; SERUM ; MEG3
语种英语
WOS记录号WOS:000470676100027
出版者WALTER DE GRUYTER GMBH
版本出版稿
源URL[http://202.127.25.144/handle/331004/1309]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Shanghai Jiao Tong Univ, Ruijin Hosp, Gen Surg Dept, Sch Med, Shanghai, Peoples R China;
2.Guangzhou Med Univ, Canc Hosp & Inst, Guangzhou, Guangdong, Peoples R China;
3.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Key Lab Tissue Microenvironm & Tumor,Shanghai, Room 1126,Biol Res Bldg A,320 Yueyang Rd, Shanghai 200025, Peoples R China,
推荐引用方式
GB/T 7714		 Liu, Hanshao,Chen, Aijun,Tan, Dan,et al. A pilot study of new promising non-coding RNA diagnostic biomarkers for early-stage colorectal cancers[J]. CLINICAL CHEMISTRY AND LABORATORY MEDICINE,2019,57(7):1073-1083.
APA Liu, Hanshao.,Chen, Aijun.,Tan, Dan.,Zhang, Wenpeng.,Wang, Mingliang.,...&,.(2019).A pilot study of new promising non-coding RNA diagnostic biomarkers for early-stage colorectal cancers.CLINICAL CHEMISTRY AND LABORATORY MEDICINE,57(7),1073-1083.
MLA Liu, Hanshao,et al."A pilot study of new promising non-coding RNA diagnostic biomarkers for early-stage colorectal cancers".CLINICAL CHEMISTRY AND LABORATORY MEDICINE 57.7(2019):1073-1083.

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来源：上海营养与健康研究所

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