Association of SLRPs with carotid artery atherosclerosis in essential hypertensive patients
文献类型：期刊论文
| 作者 | Yang, Yan1,2; Wu, Qi-hong1,2; Li, Yan1,2; Gao, Ping-jin1,2; Gao, Ping-jin3; , |
| 刊名 | JOURNAL OF HUMAN HYPERTENSION
 |
| 出版日期 | 2018 |
| 卷号 | 32期号:8页码:564-571 |
| 关键词 | DNA methylation Epigenetic clock Epithelialmesenchymal transition |
| ISSN号 | 0950-9240 |
| DOI | 10.1038/s41371-018-0077-7 |
| 文献子类 | Article |
| 英文摘要 | Recent research suggested that certain small leucine-rich repeat proteoglycans (SLRPs) were involved in the development of atherosclerosis. The present study investigated the relationship between carotid atherosclerosis plaque and the circulating levels of some SLRPs, including decorin, lumican, and osteoglycin, in essential hypertension. In total, 176 essential hypertensive patients were recruited (mean age 62.1 +/- 9.4, male 56.8%) in this study and were classified into two groups: patients with carotid artery plaque (n = 105, 60%) and patients without carotid artery plaque (n = 71, 40%). Patients with carotid artery plaque had higher serum concentration of lumican than patients without carotid plaque (58.0 +/- 1.6 vs. 52.3 +/- 2.1 ng/ml, p = 0.04) after adjusting for conventional cardiovascular risk factors. There were no differences in decorin and osteoglycin between the two groups. Multivariable logistic regression analysis revealed that lumican levels (Odds ratio (OR) per standard deviation increase, 1.598; 95% confidence interval (CI), 1.012 similar to 2.523; p = 0.04), 24-h mean systolic blood pressure (OR, 1.045; 95% CI, 1.012 similar to 1.079; p = 0.006) and the use of angiotensin receptor blocker (OR, 2.813; 95% CI, 1.023 similar to 7.734; p = 0.045) were independently associated with carotid artery plaque. Besides carotid artery plaque, lumican was related to impaired glucose tolerance (r = 0.162, p = 0.046) and adversely related to osteoglycin (r = -0.273, p < 0.001), whereas unrelated to age, sex, BMI, diabetes, blood pressure, serum lipids, high-sensitivity C-reactive protein, or carotid intima-media thickness in univariate correlation analyses. Circulating lumican was independently associated with carotid atherosclerosis plaque in essential hypertensive patients, indicating that SLRPs might be used as a promising molecular marker for atherosclerosis. |
| 学科主题 | Cardiovascular System & Cardiology |
| WOS关键词 | DIFFERENTIAL EXPRESSION ; CARDIOVASCULAR EVENTS ; SAPHENOUS-VEIN ; DEFICIENT MICE ; LUMICAN ; DISEASE ; FIBROMODULIN ; OSTEOGLYCIN ; DECORIN ; PROTEOGLYCANS |
| 语种 | 英语 |
| WOS记录号 | WOS:000445200100005 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1311]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Key Lab Vasc Biol, State Key Lab Med Genom, Shanghai, Peoples R China; 2.Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Hypertens, Dept Hypertens,Sch Med, Shanghai, Peoples R China; 3.Chinese Acad Sci, Inst Hlth Sci, Shanghai Inst Biol Sci, Lab Vasc Biol, Shanghai, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Yang, Yan,Wu, Qi-hong,Li, Yan,et al. Association of SLRPs with carotid artery atherosclerosis in essential hypertensive patients[J]. JOURNAL OF HUMAN HYPERTENSION,2018,32(8):564-571. |
| APA | Yang, Yan,Wu, Qi-hong,Li, Yan,Gao, Ping-jin,Gao, Ping-jin,&,.(2018).Association of SLRPs with carotid artery atherosclerosis in essential hypertensive patients.JOURNAL OF HUMAN HYPERTENSION,32(8),564-571. |
| MLA | Yang, Yan,et al."Association of SLRPs with carotid artery atherosclerosis in essential hypertensive patients".JOURNAL OF HUMAN HYPERTENSION 32.8(2018):564-571. |
入库方式： OAI收割
来源：上海营养与健康研究所
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