Plasma-3 and-6 fatty acids in thyroid diseases
文献类型：期刊论文
| 作者 | Li, Xiang1; Dai, Qi1; Chen, Fuxue1; Li, Hui2; Zhao, Jing3; Gao, Ying3; Huang, Chaoran4; Jin, Langping5; Yang, Fan5; Wang, Ouchen5 |
| 刊名 | ONCOLOGY LETTERS
 |
| 出版日期 | 2018 |
| 卷号 | 16期号:4页码:5433-5440 |
| 关键词 | fatty acids thyroid adenoma thyroid cancer nodular goiter |
| ISSN号 | 1792-1074 |
| DOI | 10.3892/ol.2018.9288 |
| 文献子类 | Article |
| 英文摘要 | The incidences of nodular goiter (NG), thyroid adenoma (TA), and thyroid cancer (TC) are increasing rapidly; however, the etiologies of these diseases remain unclear. The present study aimed to evaluate the differences in plasma fatty acids among these three thyroid diseases to facilitate etiological research. Four -3 and seven -6 polyunsaturated fatty acids were measured from 97 TC, 14 TA and 11 NG patient plasma samples with gas chromatography-flame ionization detector. Fatty acids levels were expressed as the percentage of each fatty acid out of the total fatty acids evaluated. The present study identified that the level of 22:6n-3 [median, interquartile range (IQR)] was significantly increased in TA (5.2%, 4.3-6.4%) compared with NG (3.6%, 3.1-4.6%) and TC patients (4.2%, 3.2-4.8%). Though not statistically significant, the levels of 20:5n-3 and 22:5n-3 demonstrated a similar pattern. The level of 22:4n-6 expressed (median, IQR) was significantly increased in NG patients (0.21%, 0.18-0.26%) compared with TA (0.16%, 0.15-0.18%) and TC (0.17%, 0.14-0.22%) patients. Furthermore the fatty acids 18:3n-6, 20:2n-6, 20:3n-6, 20:4:6, and 22:5n-6 demonstrated a similar but statistically insignificant pattern. This suggests that different fatty acids exhibit various etiological roles in NG, TA and TC and warrant further study. |
| 学科主题 | Oncology |
| WOS关键词 | CANCER STATISTICS ; RISK ; CARCINOMA ; POPULATION ; PROFILES ; CHILDREN ; ADENOMA ; TUMORS |
| 语种 | 英语 |
| WOS记录号 | WOS:000444990700172 |
| 出版者 | SPANDIDOS PUBL LTD |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1312]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China; 2.Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, 320 Yueyang Rd, Shanghai 200031, Peoples R China; 4.Shanghai Univ Tradit Chinese Med, Shanghai 201203, Peoples R China; 5.Wenzhou Med Univ, Affiliated Hosp 1, Dept Surg Oncol, 2 Fuxuexiang Rd, Wenzhou 325000, Zhejiang, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Li, Xiang,Dai, Qi,Chen, Fuxue,et al. Plasma-3 and-6 fatty acids in thyroid diseases[J]. ONCOLOGY LETTERS,2018,16(4):5433-5440. |
| APA | Li, Xiang.,Dai, Qi.,Chen, Fuxue.,Li, Hui.,Zhao, Jing.,...&,.(2018).Plasma-3 and-6 fatty acids in thyroid diseases.ONCOLOGY LETTERS,16(4),5433-5440. |
| MLA | Li, Xiang,et al."Plasma-3 and-6 fatty acids in thyroid diseases".ONCOLOGY LETTERS 16.4(2018):5433-5440. |
入库方式： OAI收割
来源：上海营养与健康研究所
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