Aberrant MRP14 expression in thyroid follicular cells mediates chemokine secretion through the IL-1 beta/MAPK pathway in Hashimoto's thyroiditis
文献类型：期刊论文
| 作者 | Luo, Xuan1; Zheng, Tingting1; Mao, Chaoming1; Dong, Xin1; Mou, Xiao1; Xu, Chengcheng1; Lu, Qingyan1; Liu, Baocui1; Mao, Chaoming2; Wang, Shengjun3 |
| 刊名 | ENDOCRINE CONNECTIONS
 |
| 出版日期 | 2018 |
| 卷号 | 7期号:6页码:850-858 |
| 关键词 | Hashimoto's thyroiditis IL-1 beta/MAPK MRP14 chemokine |
| ISSN号 | 2049-3614 |
| DOI | 10.1530/EC-18-0019 |
| 文献子类 | Article |
| 英文摘要 | Myeloid-related protein 14 (MRP14) is responsible for inflammatory reactions. However, the correlation between MRP14 and Hashimoto's thyroiditis (HT) is still not clear. In this study, we examined the status of MRP14 in thyroid tissues and sera of HT patients and explored the mechanism of IL-1 beta-mediated regulation of MRP14 expression, as well as the effects of MRP14 on pro-inflammatory chemokine secretion in thyroid follicular cells (TFCs), to elucidate the role of MRP14 in HT development. Our results showed dramatically increased MRP14 expression in thyroid tissues and sera from HT patients. In addition, IL-1 beta significantly promoted the expression of MRP14 in TFCs, which was mediated by activation of the MAPK/NF-kappa B signalling pathway. More importantly, IL-1 beta induced the secretion of the chemokines GRO-2, CXCL9 and CCL22, which was dependent on the regulation of MRP14 in TFCs. Therefore, these findings suggested that under pro-inflammatory conditions, TFCs secreted chemokines with the help of MRP14 regulation, which might suggest a potential pathological mechanism of lymphocyte infiltration into the thyroid gland in HT. |
| 学科主题 | Endocrinology & Metabolism |
| WOS关键词 | MICROVASCULAR ENDOTHELIAL-CELLS ; EPITHELIAL-CELLS ; GRAVES-DISEASE ; INFLAMMATORY RESPONSE ; INTERFERON-GAMMA ; S100 PROTEIN ; AUTOIMMUNE ; RECEPTOR ; SERUM ; INTERLEUKIN-1 |
| 语种 | 英语 |
| WOS记录号 | WOS:000435691300008 |
| 出版者 | BIOSCIENTIFICA LTD |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1316]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Jiangsu Univ, Affiliated Hosp, Dept Nucl Med, Zhenjiang, Peoples R China; 2.Jiangsu Univ, Affiliated Hosp, Inst Oncol, Zhenjiang, Peoples R China; 3.Jiangsu Univ, Sch Med, Dept Lab Immunol, Zhenjiang, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai, Peoples R China; 5.Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Luo, Xuan,Zheng, Tingting,Mao, Chaoming,et al. Aberrant MRP14 expression in thyroid follicular cells mediates chemokine secretion through the IL-1 beta/MAPK pathway in Hashimoto's thyroiditis[J]. ENDOCRINE CONNECTIONS,2018,7(6):850-858. |
| APA | Luo, Xuan.,Zheng, Tingting.,Mao, Chaoming.,Dong, Xin.,Mou, Xiao.,...&,.(2018).Aberrant MRP14 expression in thyroid follicular cells mediates chemokine secretion through the IL-1 beta/MAPK pathway in Hashimoto's thyroiditis.ENDOCRINE CONNECTIONS,7(6),850-858. |
| MLA | Luo, Xuan,et al."Aberrant MRP14 expression in thyroid follicular cells mediates chemokine secretion through the IL-1 beta/MAPK pathway in Hashimoto's thyroiditis".ENDOCRINE CONNECTIONS 7.6(2018):850-858. |
入库方式： OAI收割
来源：上海营养与健康研究所
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