Modes of genetic adaptations underlying functional innovations in the rumen
文献类型：期刊论文
| 作者 | Pan, Xiangyu22; Cai, Yudong22; Li, Zongjun22; Chen, Xianqing21; Heller, Rasmus20; Wang, Nini22; Wang, Yu22; Zhao, Chen22; Wang, Yong17,18,19; Xu, Han22 |
| 刊名 | SCIENCE CHINA-LIFE SCIENCES
 |
| 出版日期 | 2020-11-05 |
| 页码 | 21 |
| ISSN号 | 1674-7305 |
| 关键词 | rumen innovations comparative transcriptomics comparative genomics evo-devo evolution of organs |
| DOI | 10.1007/s11427-020-1828-8 |
| 英文摘要 | The rumen is the hallmark organ of ruminants and hosts a diverse ecosystem of microorganisms that facilitates efficient digestion of plant fibers. We analyzed 897 transcriptomes from three Cetartiodactyla lineages: ruminants, camels and cetaceans, as well as data from ruminant comparative genomics and functional assays to explore the genetic basis of rumen functional innovations. We identified genes with relatively high expression in the rumen, of which many appeared to be recruited from other tissues. These genes show functional enrichment in ketone body metabolism, regulation of microbial community, and epithelium absorption, which are the most prominent biological processes involved in rumen innovations. Several modes of genetic change underlying rumen functional innovations were uncovered, including coding mutations, genes newly evolved, and changes of regulatory elements. We validated that the key ketogenesis rate-limiting gene (HMGCS2) with five ruminant-specific mutations was under positive selection and exhibits higher synthesis activity than those of other mammals. Two newly evolved genes (LYZ1 and DEFB1) are resistant to Gram-positive bacteria and thereby may regulate microbial community equilibrium. Furthermore, we confirmed that the changes of regulatory elements accounted for the majority of rumen gene recruitment. These results greatly improve our understanding of rumen evolution and organ evo-devo in general. |
| WOS关键词 | EPIDERMAL DIFFERENTIATION ; PHYLOGENETIC ANALYSIS ; EXPRESSION ANALYSIS ; EVOLUTION ; STOMACH ; PACKAGE ; DOMAIN ; ANNOTATION ; PHYSIOLOGY ; STRATEGY |
| 资助项目 | National Natural Science Foundation of China[31822052] ; National Natural Science Foundation of China[31572381] ; National Natural Science Foundation of China[31660644] ; National Natural Science Foundation of China[41422604] ; National Thousand Youth Talents Plan ; Villum Foundation[VKR 023447] ; Independent Research Fund Denmark[8049-00098B] |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
| 语种 | 英语 |
| 出版者 | SCIENCE PRESS |
| WOS记录号 | WOS:000587977700002 |
| 资助机构 | National Natural Science Foundation of China ; National Thousand Youth Talents Plan ; Villum Foundation ; Independent Research Fund Denmark |
| 源URL | [http://ir.idsse.ac.cn/handle/183446/7994]  |
| 专题 | 深海科学研究部_深海生物学研究室_海洋哺乳动物与海洋生物声学研究组 |
| 通讯作者 | Wang, Wen; Jiang, Yu |
| 作者单位 | 1.Univ Western Australia, Inst Agr, Crawley, WA 6009, Australia 2.Univ Western Australia, Sch Anim Biol, Crawley, WA 6009, Australia 3.Lanzhou Univ, Coll Life Sci, State Key Lab Grassland Agroecosyst, Lanzhou 730000, Peoples R China 4.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Yunnan, Peoples R China 5.BGI Shenzhen, China Natl GeneBank, Shenzhen 518083, Peoples R China 6.Univ Copenhagen, Dept Biol, Sect Ecol & Evolut, DK-2100 Copenhagen, Denmark 7.Chinese Acad Agr Sci, Inst Special Anim & Plant Sci, Dept Special Econ Anim Nutr & Feed Sci, Changchun 130112, Peoples R China 8.Northwest A&F Univ, Shaanxi Ctr Stem Cells Engn & Technol, Coll Vet Med, Yangling 712100, Shaanxi, Peoples R China 9.Nanjing Agr Univ, Coll Anim Sci & Technol, Nanjing 210095, Peoples R China 10.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China |
| 推荐引用方式 GB/T 7714 | Pan, Xiangyu,Cai, Yudong,Li, Zongjun,et al. Modes of genetic adaptations underlying functional innovations in the rumen[J]. SCIENCE CHINA-LIFE SCIENCES,2020:21. |
| APA | Pan, Xiangyu.,Cai, Yudong.,Li, Zongjun.,Chen, Xianqing.,Heller, Rasmus.,...&Jiang, Yu.(2020).Modes of genetic adaptations underlying functional innovations in the rumen.SCIENCE CHINA-LIFE SCIENCES,21. |
| MLA | Pan, Xiangyu,et al."Modes of genetic adaptations underlying functional innovations in the rumen".SCIENCE CHINA-LIFE SCIENCES (2020):21. |
入库方式： OAI收割
来源：深海科学与工程研究所
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