Prioritizing selected PPCPs on the basis of environmental and toxicogenetic concerns: A toxicity estimation to confirmation approach
文献类型：期刊论文
| 作者 | Junaid, Muhammad1,2,3; Wang, Yan1,3; Hamid, Naima1,3; Deng, Shun1; Li, Wei-Guo2; Pei, De-Sheng1,2,3
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| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
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| 出版日期 | 2019-12-15 |
| 卷号 | 380页码:12 |
| ISSN号 | 0304-3894 |
| 关键词 | Developmental toxicity Zebrafish HEK293T cells Detoxification Ecological risks |
| DOI | 10.1016/j.jhazmat.2019.120828 |
| 通讯作者 | Pei, De-Sheng(peids@cigit.ac.cn) |
| 英文摘要 | Pharmaceuticals and personal care products (PPCPs), the pollutants of emerging concerns, present potential risks to the ecological environment. This study focused on the prioritization of widely used selected PPCPs belonging to two categories:personal care products (PCPs) and non-steroidal anti-inflammatory drugs (NSAIDs). We predicted the toxicogenetic endpoints of PPCPs and then confirmed them using experimental approaches. Our results revealed a significant similarity in the findings obtained through both approaches, indicating NSAIDs with relatively high environmental impacts and in vitro/vivo toxicity. Experimental approach revealed that musk xylene (MX) from PCPs and DIC from NSAIDs as individual chemicals of priority concern showed elevated environmental impacts and significantly induced pi3k-akt-mTOR in vitro. Similarly, propyl paraben (PP) from PCPs and diclofenac (DIC) from NSAIDs caused significant cytotoxicity and DNA damage in vitro. Moreover, PP and MX from the PCPs group and naproxen (NAP) and DIC from the NSAIDs group induced developmental toxicity and perturbations to phases I, II, and III detoxification pathways in vivo. In addition, MX and DIC as priority PPCPs inhibited hematopoiesis and hepatogenesis in vivo. Apart from the specific effects, PPCPs can be ranked as: MX > PP > methylparaben (MP) for PCPs, and DIC > NAP > ibuprofen (IBU) for NSAIDs, regarding their toxic and environmental concerns. |
| 资助项目 | CAS Team Project of the Belt and Road ; Three Hundred Leading Talents in Scientific and Technological Innovation Program of Chongqing[CSTCCXLJRC201714] ; Program of China-Sri Lanka Joint Research and Demonstration Center for Water Technology by Chinese Academy of Sciences, China ; China-Sri Lanka Joint Center for Education and Research by Chinese Academy of Sciences, China |
| WOS研究方向 | Engineering ; Environmental Sciences & Ecology |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:000491683300012 |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/10316]  |
| 专题 | 中国科学院重庆绿色智能技术研究院 |
| 通讯作者 | Pei, De-Sheng |
| 作者单位 | 1.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Key Lab Reservoir Aquat Environm, Chongqing 400714, Peoples R China 2.Henan Normal Univ, Coll Life Sci, Xinxiang 453007, Henan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Junaid, Muhammad,Wang, Yan,Hamid, Naima,et al. Prioritizing selected PPCPs on the basis of environmental and toxicogenetic concerns: A toxicity estimation to confirmation approach[J]. JOURNAL OF HAZARDOUS MATERIALS,2019,380:12. |
| APA | Junaid, Muhammad,Wang, Yan,Hamid, Naima,Deng, Shun,Li, Wei-Guo,&Pei, De-Sheng.(2019).Prioritizing selected PPCPs on the basis of environmental and toxicogenetic concerns: A toxicity estimation to confirmation approach.JOURNAL OF HAZARDOUS MATERIALS,380,12. |
| MLA | Junaid, Muhammad,et al."Prioritizing selected PPCPs on the basis of environmental and toxicogenetic concerns: A toxicity estimation to confirmation approach".JOURNAL OF HAZARDOUS MATERIALS 380(2019):12. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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