A multifunctional surfactant catalyst inspired by hydrolases
文献类型：期刊论文
| 作者 | Nothling, Mitchell D.6; Xiao, Zeyun3 ; Hill, Nicholas S.2; Blyth, Mitchell T.2; Bhaskaran, Ayana2; Sani, Marc-Antoine1; Espinosa-Gomez, Andrea6; Ngov, Kevin6; White, Jonathan1; Buscher, Tim4
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| 刊名 | SCIENCE ADVANCES
 |
| 出版日期 | 2020-04-01 |
| 卷号 | 6期号:14页码:12 |
| ISSN号 | 2375-2548 |
| DOI | 10.1126/sciadv.aaz0404 |
| 通讯作者 | Connal, Luke A.(luke.connal@anu.edu.au) |
| 英文摘要 | The remarkable power of enzymes to undertake catalysis frequently stems from their grouping of multiple, complementary chemical units within close proximity around the enzyme active site. Motivated by this, we report here a bioinspired surfactant catalyst that incorporates a variety of chemical functionalities common to hydrolytic enzymes. The textbook hydrolase active site, the catalytic triad, is modeled by positioning the three groups of the triad (-OH, -imidazole, and -CO2H) on a single, trifunctional surfactant molecule. To support this, we recreate the hydrogen bond donating arrangement of the oxyanion hole by imparting surfactant functionality to a guanidinium headgroup. Self-assembly of these amphiphiles in solution drives the collection of functional headgroups into close proximity around a hydrophobic nano-environment, affording hydrolysis of a model ester at rates that challenge alpha-chymotrypsin. Structural assessment via NMR and XRD, paired with MD simulation and QM calculation, reveals marked similarities of the co-micelle catalyst to native enzymes. |
| 资助项目 | U.S. Army International Technology Centre Pacific ITC-PAC[FA5209-14-C-0017] ; Australian Research Council (ARC)[DP200100535] ; Australia Science Endowment Fund (SIEF) ; ARC Centre of Excellence for Electromaterials Science[CE140100012] ; ARC Laureate Fellowship[FL170100041] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000523302400023 |
| 出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/10752]  |
| 专题 | 中国科学院重庆绿色智能技术研究院 |
| 通讯作者 | Connal, Luke A. |
| 作者单位 | 1.Univ Melbourne, Sch Chem, Bio21 Inst, Melbourne, Vic 3010, Australia 2.Australian Natl Univ, Res Sch Chem, Canberra, ACT 2601, Australia 3.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China 4.Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA 5.Australian Natl Univ, ARC Ctr Excellence Electromat Sci, Res Sch Chem, Canberra, ACT 2601, Australia 6.Univ Melbourne, Dept Chem & Biomol Engn, Melbourne, Vic 3010, Australia |
| 推荐引用方式 GB/T 7714 | Nothling, Mitchell D.,Xiao, Zeyun,Hill, Nicholas S.,et al. A multifunctional surfactant catalyst inspired by hydrolases[J]. SCIENCE ADVANCES,2020,6(14):12. |
| APA | Nothling, Mitchell D..,Xiao, Zeyun.,Hill, Nicholas S..,Blyth, Mitchell T..,Bhaskaran, Ayana.,...&Connal, Luke A..(2020).A multifunctional surfactant catalyst inspired by hydrolases.SCIENCE ADVANCES,6(14),12. |
| MLA | Nothling, Mitchell D.,et al."A multifunctional surfactant catalyst inspired by hydrolases".SCIENCE ADVANCES 6.14(2020):12. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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