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Single cell imaging with near-field terahertz scanning microscopy

文献类型：期刊论文

作者Li, Zaoxia5,6,7; Yan, Shihan5,7; Zang, Ziyi5,6,7; Geng, Guoshuai5,6,7; Yang, Zhongbo5,7; Li, Jiang4,8; Wang, Lihua4,8; Yao, Chunyan3; Cui, Hong-Liang5,6,7; Chang, Chao1,2
刊名CELL PROLIFERATION
出版日期2020-04-01
卷号53期号:4页码:7
关键词dehydration near-field imaging photoconductive antenna microprobe scanning microscope single cell terahertz
ISSN号0960-7722
DOI10.1111/cpr.12788
通讯作者Yao, Chunyan(yaochunyan@tmmu.edu.cn) ; Wang, Huabin(wanghuabin@cigit.ac.cn)
英文摘要Objectives Terahertz (THz)-based imaging techniques hold great potential for biological and biomedical applications, which nevertheless are hampered by the low spatial resolution of conventional THz imaging systems. In this work, we report a high-performance photoconductive antenna microprobe-based near-field THz time-domain spectroscopy scanning microscope. Materials and methods A single watermelon pulp cell was prepared on a clean quartz slide and covered by a thin polyethylene film. The high performance near-field THz microscope was developed based on a coherent THz time-domain spectroscopy system coupled with a photoconductive antenna microprobe. The sample was imaged in transmission mode. Results We demonstrate the direct imaging of the morphology of single watermelon pulp cells in the natural dehydration process with our near-field THz microscope. Conclusions Given the label-free and non-destructive nature of THz detection techniques, our near-field microscopy-based single-cell imaging approach sheds new light on studying biological samples with THz.
WOS研究方向Cell Biology
语种英语
WOS记录号WOS:000528669500004
出版者WILEY
源URL[http://119.78.100.138/handle/2HOD01W0/10914]  
专题中国科学院重庆绿色智能技术研究院
通讯作者Yao, Chunyan; Wang, Huabin
作者单位1.Natl Innovat Inst Def Technol, Adv Interdisciplinary Technol Res Ctr, Beijing, Peoples R China
2.Tsinghua Univ, Dept Engn Phys, Beijing, Peoples R China
3.Third Mil Med Univ, Southwest Hosp, Dept Transfus Med, Army Med Univ, Chongqing 400038, Peoples R China
4.Chinese Acad Sci, Shanghai Adv Res Inst, Zhangjiang Lab, Shanghai Synchrotron Radiat Facil,Bioimaging Ctr, Shanghai, Peoples R China
5.Chinese Acad Sci, Chongqing Engn Res Ctr High Resolut & Three Dimen, Chongqing Inst Green & Intelligent Technol, Chongqing, Peoples R China
6.Jilin Univ, Coll Instrumentat & Elect Engn, Changchun, Peoples R China
7.Chinese Acad Sci, Ctr Appl Phys, Chongqing Inst Green & Intelligent Technol, Chongqing, Peoples R China
8.Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, CAS Key Lab Interfacial Phys & Technol, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Li, Zaoxia,Yan, Shihan,Zang, Ziyi,et al. Single cell imaging with near-field terahertz scanning microscopy[J]. CELL PROLIFERATION,2020,53(4):7.
APA Li, Zaoxia.,Yan, Shihan.,Zang, Ziyi.,Geng, Guoshuai.,Yang, Zhongbo.,...&Wang, Huabin.(2020).Single cell imaging with near-field terahertz scanning microscopy.CELL PROLIFERATION,53(4),7.
MLA Li, Zaoxia,et al."Single cell imaging with near-field terahertz scanning microscopy".CELL PROLIFERATION 53.4(2020):7.

入库方式： OAI收割

来源：重庆绿色智能技术研究院

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