Nanopore Detection of Metal Ions: Current Status and Future Directions
文献类型：期刊论文
| 作者 | Roozbahani, Golbarg Mohammadi2; Chen, Xiaohan2; Zhang, Youwen2; Wang, Liang1,3 ; Guan, Xiyun2
|
| 刊名 | SMALL METHODS
 |
| 出版日期 | 2020-08-09 |
| 页码 | 20 |
| 关键词 | biomolecules chemical reactions metal ion molecular translocation nanopore |
| ISSN号 | 2366-9608 |
| DOI | 10.1002/smtd.202000266 |
| 通讯作者 | Wang, Liang(wangliang83@cigit.ac.cn) ; Guan, Xiyun(xguan5@iit.edu) |
| 英文摘要 | In this review, recent research efforts that aimed at developing nanopore sensors for detection of metal ions, which play a crucial role in environmental safety and human health, are highlighted. Protein pores use three stochastic sensing-based strategies for metal ion detection. The first strategy is to construct engineered nanopores with metal ion binding sites, so that the interaction between the target analytes and the nanopore can slow the movement of metal ions in the nanochannel. Second, large molecules such as nucleic acids and especially peptides can be utilized as external selective molecular probes to detect metal ions based on the conformational change of the ligand molecules induced by the metal ion-ligand chelation/coordination interaction. Third, enzymatic reactions can also be used as an alternative to the molecule probe strategy in the situation that a sensitive and selective probe molecule for the target analyte is difficult to obtain. On the other hand, by taking advantage of steady-state analysis, synthetic nanopores mainly use two strategies (modification and modification-free) to detect metals. Given the advantages of high sensitivity and selectivity, and label-free detection, nanopore-based metal ion sensors should find useful application in many fields, including environmental monitoring, medical diagnosis, and so on. |
| 资助项目 | National Institutes of Health[2R15GM110632-02] ; National Science Foundation[1708596] ; Pioneer Hundred Talents Program of Chinese Academy of Sciences (CAS) ; National Natural Science Foundation of China[31800711] ; Chongqing Talents[CQYC201905007] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000557372600001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/11571]  |
| 专题 | 中国科学院重庆绿色智能技术研究院 |
| 通讯作者 | Wang, Liang; Guan, Xiyun |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.IIT, Dept Chem, Chicago, IL 60616 USA 3.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China |
| 推荐引用方式 GB/T 7714 | Roozbahani, Golbarg Mohammadi,Chen, Xiaohan,Zhang, Youwen,et al. Nanopore Detection of Metal Ions: Current Status and Future Directions[J]. SMALL METHODS,2020:20. |
| APA | Roozbahani, Golbarg Mohammadi,Chen, Xiaohan,Zhang, Youwen,Wang, Liang,&Guan, Xiyun.(2020).Nanopore Detection of Metal Ions: Current Status and Future Directions.SMALL METHODS,20. |
| MLA | Roozbahani, Golbarg Mohammadi,et al."Nanopore Detection of Metal Ions: Current Status and Future Directions".SMALL METHODS (2020):20. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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