Synthesis of Vitamin B-12-Antibiotic Conjugates with Greatly Improved Activity against Gram-Negative Bacteria
文献类型：期刊论文
| 作者 | Zhao, Sheng1; Wang, Zhi-Peng2; Wen, Xumei1; Li, Siyu1; Wei, Guoxing1; Guo, Jian1; He, Yun1 |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2020-08-21 |
| 卷号 | 22期号:16页码:6632-6636 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.0c02403 |
| 通讯作者 | Guo, Jian(jian.guo@cqu.edu.cn) ; He, Yun(yun.he@cqu.edu.cn) |
| 英文摘要 | There is an urgent need to discover new antibiotics and improve the efficacy of known antibiotics against Gram-negative bacteria. "Trojan horse" conjugates are novel and promising antibiotics. Herein we report the design and synthesis of vitamin-B-12-ampicillin conjugates, which exhibited more than 500 times improved activity against Escherichia coli compared with ampicillin itself. Our studies demonstrate that the vitamin-B-12 uptake pathway could be employed for effective antibiotic delivery and efficacy enhancement. |
| 资助项目 | Natural Science Foundation of Chongqing, China[cstc2019jcyjzdxmX0021] ; Natural Science Foundation of Chongqing, China[cstc2019jcyj-msxmX0057] ; Fundamental Rese arch Funds for the Central Universities[2019CDQYYX018] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000563755700080 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/11644]  |
| 专题 | 中国科学院重庆绿色智能技术研究院 |
| 通讯作者 | Guo, Jian; He, Yun |
| 作者单位 | 1.Chongqing Univ, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, Chongqing 401331, Peoples R China 2.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Sheng,Wang, Zhi-Peng,Wen, Xumei,et al. Synthesis of Vitamin B-12-Antibiotic Conjugates with Greatly Improved Activity against Gram-Negative Bacteria[J]. ORGANIC LETTERS,2020,22(16):6632-6636. |
| APA | Zhao, Sheng.,Wang, Zhi-Peng.,Wen, Xumei.,Li, Siyu.,Wei, Guoxing.,...&He, Yun.(2020).Synthesis of Vitamin B-12-Antibiotic Conjugates with Greatly Improved Activity against Gram-Negative Bacteria.ORGANIC LETTERS,22(16),6632-6636. |
| MLA | Zhao, Sheng,et al."Synthesis of Vitamin B-12-Antibiotic Conjugates with Greatly Improved Activity against Gram-Negative Bacteria".ORGANIC LETTERS 22.16(2020):6632-6636. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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