中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Acute and chronic effects of polystyrene microplastics on brine shrimp: First evidence highlighting the molecular mechanism through transcriptome analysis

文献类型:期刊论文

作者Suman, Thodhal Yoganandham2,3; Jia, Pan-Pan3; Li, Wei-Guo2; Junaid, Muhammad1; Xin, Guang-Yuan2,3; Wang, Yan3; Pei, De-Sheng2,3
刊名JOURNAL OF HAZARDOUS MATERIALS
出版日期2020-12-05
卷号400页码:13
ISSN号0304-3894
关键词Polystyrene microplastics Artemia salina Bioaccumulation Molecular toxicology Transcriptome
DOI10.1016/j.jhazmat.2020.123220
通讯作者Pei, De-Sheng(peids@cigit.ac.cn)
英文摘要Microplastics contamination is one of the leading environmental catastrophes for the marine ecosystem, but the molecular toxicity mechanism of those microplastics remains elusive. This study aims to determine the acute and chronic toxicity after exposure to polystyrene microplastics in brine shrimp with various concentrations. Our results demonstrated that acute exposure to polystyrene microplastics induced no significant effects on the survival of brine shrimp. Interestingly, the concentration-dependent increase in both bioaccumulation and the generation of reactive oxygen species (ROS) was observed after acute and chronic exposure. Moreover, the histopathology analysis revealed the deformation of epithelial cells in the midgut region after both acute exposures at 100 mg/L and chronic exposure at 1 mg/L to polystyrene microplastics. To elucidate the underlying mechanisms of microplastics-mediated toxicity, the transcriptome analysis was performed after chronic exposure, and the result showed 721 differentially expressed genes (DEGs) associated with 156 known KEGG pathways. 292 DEGs genes were significantly upregulated and 429 genes were significantly downregulated. The transcriptome analysis further revealed the DEGs related pathways. Taken together, this study not only highlighted the negative effects but also provided detailed sequencing data from transcriptome profiling to enhance our understanding of the molecular toxicity of polystyrene microplastics in brine shrimp.
资助项目Chongqing Key Program of Basic Research and Advanced Exploration Project[cstc2019jcyj-zdxmX0035] ; Three Hundred Leading Talents in Scientific and Technological Innovation Program of Chongqing[CSTCCXLJRC201714] ; Henan Normal University ; Program of China-Sri Lanka Joint Center for Water Technology Research and Demonstration by the Chinese Academy of Sciences (CAS)/China-Sri Lanka Joint Center for Education and Research by the CAS
WOS研究方向Engineering ; Environmental Sciences & Ecology
语种英语
出版者ELSEVIER
WOS记录号WOS:000572115000003
源URL[http://119.78.100.138/handle/2HOD01W0/11838]  
专题中国科学院重庆绿色智能技术研究院
通讯作者Pei, De-Sheng
作者单位1.Peking Univ, Sch Environm & Energy, Key Lab Heavy Met Pollut Control & Reutilizat, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China
2.Henan Normal Univ, Coll Life Sci, Xinxiang 453007, Henan, Peoples R China
3.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China
推荐引用方式
GB/T 7714
Suman, Thodhal Yoganandham,Jia, Pan-Pan,Li, Wei-Guo,et al. Acute and chronic effects of polystyrene microplastics on brine shrimp: First evidence highlighting the molecular mechanism through transcriptome analysis[J]. JOURNAL OF HAZARDOUS MATERIALS,2020,400:13.
APA Suman, Thodhal Yoganandham.,Jia, Pan-Pan.,Li, Wei-Guo.,Junaid, Muhammad.,Xin, Guang-Yuan.,...&Pei, De-Sheng.(2020).Acute and chronic effects of polystyrene microplastics on brine shrimp: First evidence highlighting the molecular mechanism through transcriptome analysis.JOURNAL OF HAZARDOUS MATERIALS,400,13.
MLA Suman, Thodhal Yoganandham,et al."Acute and chronic effects of polystyrene microplastics on brine shrimp: First evidence highlighting the molecular mechanism through transcriptome analysis".JOURNAL OF HAZARDOUS MATERIALS 400(2020):13.

入库方式: OAI收割

来源:重庆绿色智能技术研究院

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