Acute and chronic effects of polystyrene microplastics on brine shrimp: First evidence highlighting the molecular mechanism through transcriptome analysis
文献类型:期刊论文
作者 | Suman, Thodhal Yoganandham2,3; Jia, Pan-Pan3; Li, Wei-Guo2; Junaid, Muhammad1; Xin, Guang-Yuan2,3; Wang, Yan3; Pei, De-Sheng2,3 |
刊名 | JOURNAL OF HAZARDOUS MATERIALS |
出版日期 | 2020-12-05 |
卷号 | 400页码:13 |
ISSN号 | 0304-3894 |
关键词 | Polystyrene microplastics Artemia salina Bioaccumulation Molecular toxicology Transcriptome |
DOI | 10.1016/j.jhazmat.2020.123220 |
通讯作者 | Pei, De-Sheng(peids@cigit.ac.cn) |
英文摘要 | Microplastics contamination is one of the leading environmental catastrophes for the marine ecosystem, but the molecular toxicity mechanism of those microplastics remains elusive. This study aims to determine the acute and chronic toxicity after exposure to polystyrene microplastics in brine shrimp with various concentrations. Our results demonstrated that acute exposure to polystyrene microplastics induced no significant effects on the survival of brine shrimp. Interestingly, the concentration-dependent increase in both bioaccumulation and the generation of reactive oxygen species (ROS) was observed after acute and chronic exposure. Moreover, the histopathology analysis revealed the deformation of epithelial cells in the midgut region after both acute exposures at 100 mg/L and chronic exposure at 1 mg/L to polystyrene microplastics. To elucidate the underlying mechanisms of microplastics-mediated toxicity, the transcriptome analysis was performed after chronic exposure, and the result showed 721 differentially expressed genes (DEGs) associated with 156 known KEGG pathways. 292 DEGs genes were significantly upregulated and 429 genes were significantly downregulated. The transcriptome analysis further revealed the DEGs related pathways. Taken together, this study not only highlighted the negative effects but also provided detailed sequencing data from transcriptome profiling to enhance our understanding of the molecular toxicity of polystyrene microplastics in brine shrimp. |
资助项目 | Chongqing Key Program of Basic Research and Advanced Exploration Project[cstc2019jcyj-zdxmX0035] ; Three Hundred Leading Talents in Scientific and Technological Innovation Program of Chongqing[CSTCCXLJRC201714] ; Henan Normal University ; Program of China-Sri Lanka Joint Center for Water Technology Research and Demonstration by the Chinese Academy of Sciences (CAS)/China-Sri Lanka Joint Center for Education and Research by the CAS |
WOS研究方向 | Engineering ; Environmental Sciences & Ecology |
语种 | 英语 |
出版者 | ELSEVIER |
WOS记录号 | WOS:000572115000003 |
源URL | [http://119.78.100.138/handle/2HOD01W0/11838] |
专题 | 中国科学院重庆绿色智能技术研究院 |
通讯作者 | Pei, De-Sheng |
作者单位 | 1.Peking Univ, Sch Environm & Energy, Key Lab Heavy Met Pollut Control & Reutilizat, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China 2.Henan Normal Univ, Coll Life Sci, Xinxiang 453007, Henan, Peoples R China 3.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China |
推荐引用方式 GB/T 7714 | Suman, Thodhal Yoganandham,Jia, Pan-Pan,Li, Wei-Guo,et al. Acute and chronic effects of polystyrene microplastics on brine shrimp: First evidence highlighting the molecular mechanism through transcriptome analysis[J]. JOURNAL OF HAZARDOUS MATERIALS,2020,400:13. |
APA | Suman, Thodhal Yoganandham.,Jia, Pan-Pan.,Li, Wei-Guo.,Junaid, Muhammad.,Xin, Guang-Yuan.,...&Pei, De-Sheng.(2020).Acute and chronic effects of polystyrene microplastics on brine shrimp: First evidence highlighting the molecular mechanism through transcriptome analysis.JOURNAL OF HAZARDOUS MATERIALS,400,13. |
MLA | Suman, Thodhal Yoganandham,et al."Acute and chronic effects of polystyrene microplastics on brine shrimp: First evidence highlighting the molecular mechanism through transcriptome analysis".JOURNAL OF HAZARDOUS MATERIALS 400(2020):13. |
入库方式: OAI收割
来源:重庆绿色智能技术研究院
浏览0
下载0
收藏0
其他版本
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。