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Role of oncogene PIM-1 in the development and progression of papillary thyroid carcinoma: Involvement of oxidative stress

文献类型：期刊论文

作者Wen, Qing-Liang1,2,3; Yi, He-Qing1,2,3; Yang, Ke1,2,3; Yin, Chang-Tian4; Yin, Wen-Juan1,2,3; Xiang, Fang-Yue5; Bao, Miao6; Shuai, Jing5; Song, Yi-Wei5; Ge, Ming-Hua4
刊名MOLECULAR AND CELLULAR ENDOCRINOLOGY
出版日期2021-03-01
卷号523
关键词Papillary thyroid carcinoma PIM-1 Oxidative stress NOX4
ISSN号0303-7207
DOI10.1016/j.mce.2020.111144
通讯作者Ge, Ming-Hua(geminghua@hmc.edu.cn) ; Zhu, Xin(zhuxin@zjcc.org.cn)
英文摘要In this study, we aimed to clarify the role of PIM-1 in papillary thyroid carcinoma (PTC) in vitro and investigate the relationship between PIM-1 and redox proteins (NOX4, SOD2, and GPX2) at the tissue and cellular levels. As a PIM-1 inhibitor, SGI-1776 inhibited cell proliferation, colony formation, migration and induced an increase in apoptosis and reactive oxygen species in two PTC cell lines (BCPAP and TPC-1). The expressions of PIM-1, SOD2 and GPX2 were downregulated after siNOX4 exposure. Immunohistochemistry in 120 PTC patients showed that all four proteins exhibited higher expression levels in PTC tissues than in adjacent normal tissues. PIM-1 expression was related to NOX4, SOD2, and GPX2 expressions. The Cancer Genome Atlas database analysis showed the significant correlation between the expression of NOX4 and PIM-1. Our results demonstrated that PIM-1 played an important oncogenic role in PTC carcinogenesis that may be related to oxidative stress.
资助项目National Natural Science Foundation of China[82072950] ; Zhejiang Province Natural Science Foundation of China[LY17H070003] ; Zhejiang Province Natural Science Foundation of China[LY20H180007]
WOS研究方向Cell Biology ; Endocrinology & Metabolism
语种英语
WOS记录号WOS:000614236500006
出版者ELSEVIER IRELAND LTD
资助机构National Natural Science Foundation of China ; Zhejiang Province Natural Science Foundation of China
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/119651]  
专题中国科学院合肥物质科学研究院
通讯作者Ge, Ming-Hua; Zhu, Xin
作者单位1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Hangzhou, Peoples R China
2.Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou 310022, Zhejiang, Peoples R China
3.Key Lab Head & Neck Canc Translat Res Zhejiang Pr, Hangzhou, Peoples R China
4.Zhejiang Prov Peoples Hosp, Dept Head & Neck Surg, Hangzhou, Peoples R China
5.Zhejiang Chinese Med Univ, Stomatol Coll, Hangzhou, Peoples R China
6.Zhejiang Univ, Affiliated Jinhua Hosp, Sch Med, Jinhua, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714		 Wen, Qing-Liang,Yi, He-Qing,Yang, Ke,et al. Role of oncogene PIM-1 in the development and progression of papillary thyroid carcinoma: Involvement of oxidative stress[J]. MOLECULAR AND CELLULAR ENDOCRINOLOGY,2021,523.
APA Wen, Qing-Liang.,Yi, He-Qing.,Yang, Ke.,Yin, Chang-Tian.,Yin, Wen-Juan.,...&Zhu, Xin.(2021).Role of oncogene PIM-1 in the development and progression of papillary thyroid carcinoma: Involvement of oxidative stress.MOLECULAR AND CELLULAR ENDOCRINOLOGY,523.
MLA Wen, Qing-Liang,et al."Role of oncogene PIM-1 in the development and progression of papillary thyroid carcinoma: Involvement of oxidative stress".MOLECULAR AND CELLULAR ENDOCRINOLOGY 523(2021).

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来源：合肥物质科学研究院

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