Lipid-oligonucleotide conjugates for bioapplications
文献类型：期刊论文
| 作者 | Li, Xiaowei1,2,3; Feng, Kejun1,2,3,4; Li, Long1,2,3; Yang, Lu1,2,3; Pan, Xiaoshu1,2,3; Yazd, Hoda Safari1,2,3; Cui, Cheng1,2,3,5,6,7,8; Li, Juan5,6; Moroz, Leonid1,2,3; Sun, Yujia1,2,3,5,6 |
| 刊名 | NATIONAL SCIENCE REVIEW
 |
| 出版日期 | 2020-12-01 |
| 卷号 | 7 |
| 关键词 | lipid-oligonucleotide DNA nanostructure biosensor biomedicine bio analysis nanoreactor |
| ISSN号 | 2095-5138 |
| DOI | 10.1093/nsr/nwaa161 |
| 通讯作者 | Tan, Weihong(tan@hnu.edu.cn) |
| 英文摘要 | Lipid-oligonucleotide conjugates (LONs) are powerful molecular-engineering materials for various applications ranging from biosensors to biomedicine. Their unique amphiphilic structures enable the self-assembly and the conveyance of information with high fidelity. In particular, LONs present remarkable potential in measuring cellular mechanical forces and monitoring cell behaviors. LONs are also essential sensing tools for intracellular imaging and have been employed in developing cell-surface-anchored DNA nanostructures for biomimetic-engineering studies. When incorporating therapeutic oligonucleotides or small-molecule drugs, LONs hold promise for targeted therapy. Moreover, LONs mediate the controllable assembly and fusion of vesicles based on DNA-strand displacements, contributing to nanoreactor construction and macromolecule delivery. In this review, we will summarize the general synthesis strategies of LONs, provide some characterization analysis and emphasize recent advances in bioanalytical and biomedical applications. We will also consider the relevant challenges and suggest future directions for building better functional LONs in nanotechnology and materials-science applications. |
| WOS关键词 | SOLID-PHASE SYNTHESIS ; SPHERICAL NUCLEIC-ACIDS ; DNA MICELLE FLARES ; IN-VIVO DELIVERY ; MOLECULAR RECOGNITION ; APTAMER-MICELLE ; VESICLE FUSION ; GENE DELIVERY ; CO-DELIVERY ; LIVE CELLS |
| 资助项目 | National Natural Science Foundation of China[21827811] ; Science and Technology Project of Hunan Province[2017XK2103] ; Hunan Provincial Key Area RD Program[2019SK2201] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000606157200025 |
| 出版者 | OXFORD UNIV PRESS |
| 资助机构 | National Natural Science Foundation of China ; Science and Technology Project of Hunan Province ; Hunan Provincial Key Area RD Program |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/119695]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Tan, Weihong |
| 作者单位 | 1.Univ Florida, Ctr Res Bio Nano Interface, Dept Chem, Hlth Canc Ctr, Gainesville, FL 32611 USA 2.Univ Florida, Dept Physiol & Funct Genom, Hlth Canc Ctr, UF Genet Inst, Gainesville, FL 32611 USA 3.Univ Florida, McKnight Brain Inst, Hlth Canc Ctr, Gainesville, FL 32611 USA 4.Huizhou Univ, Sch Chem & Mat Engn, Huizhou 516007, Peoples R China 5.Hunan Univ, Mol Sci & Biomed Lab MBL, State Key Lab Chemo Biosensing & Chemometr, Coll Chem & Chem Engn,Coll Biol, Changsha 410082, Hunan, Peoples R China 6.Hunan Univ, Aptamer Engn Ctr Hunan Prov, Changsha 410082, Hunan, Peoples R China 7.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Hangzhou 310022, Peoples R China 8.Univ Chinese Acad Sci, Canc Hosp, Hangzhou 310022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xiaowei,Feng, Kejun,Li, Long,et al. Lipid-oligonucleotide conjugates for bioapplications[J]. NATIONAL SCIENCE REVIEW,2020,7. |
| APA | Li, Xiaowei.,Feng, Kejun.,Li, Long.,Yang, Lu.,Pan, Xiaoshu.,...&Tan, Weihong.(2020).Lipid-oligonucleotide conjugates for bioapplications.NATIONAL SCIENCE REVIEW,7. |
| MLA | Li, Xiaowei,et al."Lipid-oligonucleotide conjugates for bioapplications".NATIONAL SCIENCE REVIEW 7(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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