Crystal structure of the WD40 domain of human PLRG1
文献类型：期刊论文
| 作者 | Wang, Xiaoyang1,2; Li, Yanjun3; Dai, Haiming4; Xu, Chao1,2 |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2021 |
| 卷号 | 534 |
| 关键词 | Spliceosome X-ray crystallography The nineteen complex WD40 repeats |
| ISSN号 | 0006-291X |
| DOI | 10.1016/j.bbrc.2020.11.057 |
| 通讯作者 | Xu, Chao(xuchaor@ustc.edu.cn) |
| 英文摘要 | PLRG1 is a evolutionarily conserved protein in spliceosome and plays an important role in maintaining the integral part of the splicoeosme and its proper splicing. Here we solved the high resolution crystal structure of the WD40 domain of human PLRG1 by crystallography and compared our crystal structure with the cryo-EM structure of PLRG1 bound with other splicing factors. We found that two loops of the WD40 domain become resolved upon binding to the proteins within the spliceosome. Thus our work characterize the dynamic property of PLRG1 during the spliceosome assembly by presenting its apo structure. (C) 2020 Elsevier Inc. All rights reserved. |
| WOS关键词 | SPLICEOSOME |
| 资助项目 | National Natural Science Foundation of China[31770806] ; Major/Innovative Program of the Development Foundation of the Hefei Center for Physical Science and Technology[2018CXFX007] ; Thousand Young Talent program |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000607348500022 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 资助机构 | National Natural Science Foundation of China ; Major/Innovative Program of the Development Foundation of the Hefei Center for Physical Science and Technology ; Thousand Young Talent program |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/119854]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Xu, Chao |
| 作者单位 | 1.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, MOE Key Lab Membraneless Organelles & Cellular Dy, Hefei 230027, Peoples R China 2.Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Peoples R China 3.Univ Toronto, Struct Genom Consortium, 101 Coll St, Toronto, ON M5G 1L7, Canada 4.Chinese Acad Sci, Ctr Med Phys & Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xiaoyang,Li, Yanjun,Dai, Haiming,et al. Crystal structure of the WD40 domain of human PLRG1[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2021,534. |
| APA | Wang, Xiaoyang,Li, Yanjun,Dai, Haiming,&Xu, Chao.(2021).Crystal structure of the WD40 domain of human PLRG1.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,534. |
| MLA | Wang, Xiaoyang,et al."Crystal structure of the WD40 domain of human PLRG1".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 534(2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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