Clinical Features and Short-Term Outcomes in COVID-19-Infected Patients with Cancer
文献类型：期刊论文
| 作者 | Wang, Yong1 ; Shan, Ben-Jie1; Shen, Xia-Bo2; Zheng, Chang-Cheng3; Wang, Jin-Quan4; Li, Gui-Ling5; Pan, Yue-Yin1
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| 刊名 | CANCER MANAGEMENT AND RESEARCH
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| 出版日期 | 2020 |
| 卷号 | 12 |
| 关键词 | COVID-19 cancer patients short-term outcomes lymphocyte subsets fibrin degradation product |
| ISSN号 | 1179-1322 |
| DOI | 10.2147/CMAR.S279564 |
| 通讯作者 | Li, Gui-Ling(lgl6714@163.com) ; Pan, Yue-Yin(panyueyin@ustc.edu.cn) |
| 英文摘要 | Background: Coronavirus disease 2019 (COVID-19) is an infectious disease that has been spreading very fast worldwide. Up to now, there is scarce information regarding the clinical features and short-term outcomes of infected patients with cancer. Methods: We performed a retrospective study in Wuhan Union Hospital from Feb 14, 2020, to Mar 15, 2020, China. Data were retrieved including demographic and clinical features, laboratory findings, and outcome data. Patients were classified into the discharged group and undischarged group by the 4-week outcomes from admission. Difference analysis and correlation analysis were performed between the two groups. Results: A total of 37 patients were enrolled in the study, including 27 cancer survivors in routine follow-up. Breast cancer (18.9%) was the most frequent cancer type, and common symptoms included cough (54.1%), fever (48.6%), and fatigue (27%). Lymphocytopenia and hypoproteinemia were much frequent in patients who had received chemotherapy, radiotherapy, or surgery within the past month. However, the concentration of D-dimer (median: 3.75 vs 0.43, P =0.010) and fibrin degradation products (median: 23.60 vs 1.80, P =0.002) were evidently increased in this population compared with cancer survivors. At the end of follow-up, 83.8% of the enrolled patients were discharged. Among the discharged, women (48.6%) and cancer survivors (67.6%) showed better short-term outcomes. The elevated level of FDP was significantly higher in the undischarged group (median: 21.85 vs 2.00, P =0.049). The proportion of CD3-positive lymphocyte cells and CD4-positive lymphocytes was correlated with short-term outcomes. Conclusion: Peripheral lymphocyte subset (CD3-positive and CD4-positive) on admission as a novel biomarker had a potential association with early efficacy. Cancer survivors in routine follow-up would achieve better short-term outcomes. COVID-19 patients with cancer should gain more attention and close monitoring. |
| WOS关键词 | ACUTE RESPIRATORY SYNDROME ; CORONAVIRUS ; OUTBREAK ; DISEASE ; WUHAN ; CHINA |
| 资助项目 | Key Research and Development Projects from Science and Technology Department of Anhui Province[1704a0802148] ; Key Research and Development Projects from Science and Technology Department of Anhui Province[1804h08020259] ; Fundamental Research Funds for the Central Universities[WK9110000058] ; Natural Science Foundation of Anhui Province[1908085MH260] ; Hefei Municipal Independent Innovation Policy Borrowing and Transferring Project[J2018Y01] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000596890400003 |
| 出版者 | DOVE MEDICAL PRESS LTD |
| 资助机构 | Key Research and Development Projects from Science and Technology Department of Anhui Province ; Fundamental Research Funds for the Central Universities ; Natural Science Foundation of Anhui Province ; Hefei Municipal Independent Innovation Policy Borrowing and Transferring Project |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/119944]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Li, Gui-Ling; Pan, Yue-Yin |
| 作者单位 | 1.Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Med Oncol, Div Life Sci & Med, Hefei 230001, Anhui, Peoples R China 2.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Breast Med Oncol, Hangzhou 311200, Peoples R China 3.Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Hematol, Div Life Sci & Med, Hefei 230001, Peoples R China 4.Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Intens Care Med, Div Life Sci & Med, Hefei 230036, Peoples R China 5.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Canc Ctr, Wuhan 430022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yong,Shan, Ben-Jie,Shen, Xia-Bo,et al. Clinical Features and Short-Term Outcomes in COVID-19-Infected Patients with Cancer[J]. CANCER MANAGEMENT AND RESEARCH,2020,12. |
| APA | Wang, Yong.,Shan, Ben-Jie.,Shen, Xia-Bo.,Zheng, Chang-Cheng.,Wang, Jin-Quan.,...&Pan, Yue-Yin.(2020).Clinical Features and Short-Term Outcomes in COVID-19-Infected Patients with Cancer.CANCER MANAGEMENT AND RESEARCH,12. |
| MLA | Wang, Yong,et al."Clinical Features and Short-Term Outcomes in COVID-19-Infected Patients with Cancer".CANCER MANAGEMENT AND RESEARCH 12(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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