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Breath-, air- and surface-borne SARS-CoV-2 in hospitals

文献类型：期刊论文

作者Zhou, Lian1; Yao, Maosheng2; Zhang, Xiang3; Hu, Bicheng4; Li, Xinyue2; Chen, Haoxuan2; Zhang, Lu2; Liu, Yun3; Du, Meng5; Sun, Bochao6
刊名JOURNAL OF AEROSOL SCIENCE
出版日期2021-02-01
卷号152
ISSN号0021-8502
关键词COVID-19 SARS-CoV-2 Exhaled breath Airborne transmission Surface-borne
DOI10.1016/j.jaerosci.2020.105693
通讯作者Yao, Maosheng(yao@pku.edu.cn) ; Zhu, Baoli(zhubl@jscdc.cn) ; Liu, Wenqing(wqliu@aiofm.ac.cn) ; Zhang, Yuanhang(yhzhang@pku.edu.cn)
英文摘要The COVID-19 pandemic has brought an unprecedented crisis to the global health sector. When discharging COVID-19 patients in accordance with throat or nasal swab protocols using RT-PCR, the potential risk of reintroducing the infection source to humans and the environment must be resolved. Here, 14 patients including 10 COVID-19 subjects were recruited; exhaled breath condensate (EBC), air samples and surface swabs were collected and analyzed for SARS-CoV-2 using reverse transcription-polymerase chain reaction (RT-PCR) in four hospitals with applied natural ventilation and disinfection practices in Wuhan. Here we discovered that 22.2% of COVID-19 patients (n = 9), who were ready for hospital discharge based on current guidelines, had SARS-CoV-2 in their exhaled breath (similar to 10(5) RNA copies/m(3)). Although fewer surface swabs (3.1%, n = 318) tested positive, medical equipment such as face shield frequently contacted/used by healthcare workers and the work shift floor were contaminated by SARS-CoV-2 (3-8 viruses/cm(2)). Three of the air samples (n = 44) including those collected using a robot-assisted sampler were detected positive by a digital PCR with a concentration level of 9-219 viruses/m (3). RT-PCR diagnosis using throat swab specimens had a failure rate of more than 22% in safely discharging COVID-19 patients who were otherwise still exhaling the SARS-CoV-2 by a rate of estimated similar to 1400 RNA copies per minute into the air. Direct surface contact might not represent a major transmission route, and lower positive rate of air sample (6.8%) was likely due to natural ventilation (1.6-3.3 m/s) and regular disinfection practices. While there is a critical need for strengthening hospital discharge standards in preventing re-emergence of COVID-19 spread, use of breath sample as a supplement specimen could further guard the hospital discharge to ensure the safety of the public and minimize the pandemic re-emergence risk.
资助项目Chinese Academy of Engineering Grant[2020-ZD-15] ; National Natural Science Foundation of China (NSFC)[22040101] ; NSFC Distinguished Young Scholars Fund[21725701] ; Scientific Research Fund of Jiangsu Provincial Health Committee[S2017002]
WOS研究方向Engineering ; Environmental Sciences & Ecology ; Meteorology & Atmospheric Sciences
语种英语
出版者ELSEVIER SCI LTD
WOS记录号WOS:000605111600004
资助机构Chinese Academy of Engineering Grant ; National Natural Science Foundation of China (NSFC) ; NSFC Distinguished Young Scholars Fund ; Scientific Research Fund of Jiangsu Provincial Health Committee
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/119983]  
专题中国科学院合肥物质科学研究院
通讯作者Yao, Maosheng; Zhu, Baoli; Liu, Wenqing; Zhang, Yuanhang
作者单位1.Jiangsu Prov Ctr Dis Control & Prevent, Dept Environm & Hlth, Nanjing 210009, Peoples R China
2.Peking Univ, Coll Environm Sci & Engn, Beijing 100871, Peoples R China
3.Nanjing Med Univ, Affiliated Hosp 1, Jiangsu Prov Hosp, Nanjing 210009, Peoples R China
4.Wuhan 1 Hosp, Clin Lab, Wuhan 430022, Peoples R China
5.Zhenjiang Ctr Dis Control & Prevent, Zhenjiang 212003, Jiangsu, Peoples R China
6.Yancheng Ctr Dis Control & Prevent, Yancheng 224002, Peoples R China
7.Taizhou Ctr Dis Control & Prevent, Taizhou 225306, Peoples R China
8.Suzhou Ctr Dis Control & Prevent, Suzhou 215004, Peoples R China
9.China Med Univ, Hosp 1, Shenyang 110001, Peoples R China
10.Queensland Univ Technol, WHO Collaborating Ctr Air Qual & Hlth, Sch Earth & Atmospher Sci, Int Lab Air Qual & Heath ILAQH, Brisbane, Qld 4001, Australia
推荐引用方式
GB/T 7714		 Zhou, Lian,Yao, Maosheng,Zhang, Xiang,et al. Breath-, air- and surface-borne SARS-CoV-2 in hospitals[J]. JOURNAL OF AEROSOL SCIENCE,2021,152.
APA Zhou, Lian.,Yao, Maosheng.,Zhang, Xiang.,Hu, Bicheng.,Li, Xinyue.,...&Zhang, Yuanhang.(2021).Breath-, air- and surface-borne SARS-CoV-2 in hospitals.JOURNAL OF AEROSOL SCIENCE,152.
MLA Zhou, Lian,et al."Breath-, air- and surface-borne SARS-CoV-2 in hospitals".JOURNAL OF AEROSOL SCIENCE 152(2021).

入库方式： OAI收割

来源：合肥物质科学研究院

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