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Out-of-the-Box Nanocapsules Packed with On-Demand Hydrophobic Anticancer Drugs for Lung Targeting, Esterase Triggering, and Synergy Therapy

文献类型：期刊论文

作者Zhao, Di1,2; Jiang, Kai1; Wang, Yuqi1; Cheng, Jin1; Mo, Fangli1; Luo, Tao1; Guo, Yuanyuan3; Zhang, Chuan3; Song, Jie1,4
刊名ADVANCED HEALTHCARE MATERIALS
出版日期2021-01-12
ISSN号2192-2640
关键词controllable esterase response high loading efficiency lung targeting multi-drug resistance universal drug encapsulation
DOI10.1002/adhm.202001803
通讯作者Zhao, Di(zhaodi@sit.edu.cn) ; Song, Jie(sjie@sjtu.edu.cn)
英文摘要Most anticancer drugs, particularly paclitaxel (PTX), are suffering the challenges of cancer chemotherapy due to their poor water-solubility, high toxicity under effective therapeutic dosages, and multi-drug resistance. Currently, nanoscale drug delivery systems (DDSs) represent an efficient platform to overcome the above challenges. However, those DDSs generally need a careful design of conjugation, complexation, or co-self-assembly. Herein, a facile out-of-the-box nanocapsule is developed not only to be easily packed with on-demand hydrophobic anticancer drugs (up to 76% of loading efficiency for PTX), but also to be loaded with other concomitant drugs for synergy therapy (Itraconazole (ITA) here as P-glycoprotein inhibitor for drug resistance and antiangiogenic agent for combination therapy with PTX). Three kinds of biocompatible poly(ethylene glycol) dimethacrylates (PEGDM) derivatives usually as cross-linking agents are selected and successfully constructed adequate nanocapsules with single monomer as shell materials. More importantly, as-prepared nanocapsules have abilities of esterase triggering and lung targeting. Both in vitro and in vivo studies showed that the drug-loaded nanocapsules can effectively inhibit tumor growth and vascular proliferation in PTX-resistant tumor models without apparent systemic toxicity. The above results demonstrate that the nanocapsule system provides an effective and universal strategy for lung targeting, esterase triggering, and synergy therapy.
WOS关键词IN-VITRO ; CANCER ; DELIVERY ; NANOPARTICLES ; GROWTH ; ANGIOGENESIS ; ITRACONAZOLE ; CHEMOTHERAPY ; DOCETAXEL ; MECHANISM
资助项目National Natural Science Foundation of China[81822024] ; National Natural Science Foundation of China[11761141006] ; Natural Science Foundation of Shanghai, China[19520714100] ; Natural Science Foundation of Shanghai, China[19ZR1475800] ; National Key Research and Development Program of China[2017YFC1200904] ; Medical Engineering Cross Project of Shanghai Jiaotong University[YG2017ZD07]
WOS研究方向Engineering ; Science & Technology - Other Topics ; Materials Science
语种英语
出版者WILEY
WOS记录号WOS:000606896500001
资助机构National Natural Science Foundation of China ; Natural Science Foundation of Shanghai, China ; National Key Research and Development Program of China ; Medical Engineering Cross Project of Shanghai Jiaotong University
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/120077]  
专题中国科学院合肥物质科学研究院
通讯作者Zhao, Di; Song, Jie
作者单位1.Shanghai Jiao Tong Univ, Sch Elect Informat & Elect Engn, Dept Instrument Sci & Engn, Inst Nano Biomed & Engn, Shanghai 200240, Peoples R China
2.Shanghai Inst Technol, Sch Perfume & Aroma Technol, Shanghai 201418, Peoples R China
3.Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Frontiers Sci Ctr Transformat Mol, State Key Lab Met Matrix Composites, 800 Dongchuan Rd, Shanghai 200240, Peoples R China
4.Univ Chinese Acad Sci, Canc Hosp, Chinese Acad Sci, Inst Canc & Basic Med ICBM, Hangzhou 310022, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714		 Zhao, Di,Jiang, Kai,Wang, Yuqi,et al. Out-of-the-Box Nanocapsules Packed with On-Demand Hydrophobic Anticancer Drugs for Lung Targeting, Esterase Triggering, and Synergy Therapy[J]. ADVANCED HEALTHCARE MATERIALS,2021.
APA Zhao, Di.,Jiang, Kai.,Wang, Yuqi.,Cheng, Jin.,Mo, Fangli.,...&Song, Jie.(2021).Out-of-the-Box Nanocapsules Packed with On-Demand Hydrophobic Anticancer Drugs for Lung Targeting, Esterase Triggering, and Synergy Therapy.ADVANCED HEALTHCARE MATERIALS.
MLA Zhao, Di,et al."Out-of-the-Box Nanocapsules Packed with On-Demand Hydrophobic Anticancer Drugs for Lung Targeting, Esterase Triggering, and Synergy Therapy".ADVANCED HEALTHCARE MATERIALS (2021).

入库方式： OAI收割

来源：合肥物质科学研究院

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