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Cys-functionalized AuNP substrates for improved sensing of the marine toxin STX by dynamic surface-enhanced Raman spectroscopy

文献类型：期刊论文

作者Cao, Chentai1,2; Li, Pan1; Liao, Hongmei3; Wang, Junping4; Tang, Xianghu5; Yang, Liangbao1,4
刊名ANALYTICAL AND BIOANALYTICAL CHEMISTRY
出版日期2020-07-01
卷号412
关键词Dynamic surface-enhanced Raman spectroscopy SERS probe Saxitoxin Electrostatic interaction Hydrogen bond
ISSN号1618-2642
DOI10.1007/s00216-020-02710-9
通讯作者Li, Pan(lipan2011@iim.ac.cn) ; Liao, Hongmei(549828750@qq.com) ; Yang, Liangbao(lbyang@iim.ac.cn)
英文摘要Saxitoxin (STX) as one of the most harmful and typical paralytic shellfish toxins, is posing a serious threat to environmental and human health, thus it is essential to develop a sensitive and reliable analytical method for STX detection. Herein, we proposed a strategy for rapid and sensitive detection of STX with surface-enhanced Raman spectroscopy (SERS), by employing cysteine modified gold nanoparticles (Cys-AuNPs) as SERS probe to capture STX molecules through electrostatic interactions and multiple hydrogen bonds between Cys and STX molecules. Moreover, the XPS and zeta potential results indicated that Cys could bond to AuNPs through Au-S bonds and the addition of STX could induce the efficient aggregation of Cys-AuNPs owing to the presence of electrostatic interactions and multiple hydrogen bonds between Cys and STX molecules. Furthermore, considering the high sensitivity and stability of the dynamic surface-enhanced Raman spectroscopy (D-SERS) strategy with the formation of a 3D hotspot matrix, the highly sensitive detection of STX was realized to a level of 1 x 10(-7) M by using the D-SERS strategy. Consequently, Cys-AuNPs as high affinity substrates can provide high sensitivity for the detection of STX through the D-SERS strategy.
WOS关键词SENSITIVE DETECTION ; L-CYSTEINE ; LIQUID-CHROMATOGRAPHY ; GOLD NANOPARTICLES ; SAXITOXIN ; SILVER ; STABILITY ; NEOSAXITOXIN ; APTASENSOR ; APTAMER
资助项目National Major Scientific and Technological Special Project for Significant New Drugs Development[2018ZX09J18112] ; National Science Foundation of China[61875206] ; CASHIPS Directors Fund[YZJJ2019QN13] ; Sci-tech Police Project of Anhui Province[806116381020] ; Sci-tech Police Project of Anhui Province[904038287034]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000543580600002
出版者SPRINGER HEIDELBERG
资助机构National Major Scientific and Technological Special Project for Significant New Drugs Development ; National Science Foundation of China ; CASHIPS Directors Fund ; Sci-tech Police Project of Anhui Province
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/92839]  
专题中国科学院合肥物质科学研究院
通讯作者Li, Pan; Liao, Hongmei; Yang, Liangbao
作者单位1.Chinese Acad Sci, Anhui Prov Key Lab Med Phys & Technol, Ctr Med Phys & Technol, Hefei Inst Phys Sci, Hefei 230031, Anhui, Peoples R China
2.Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China
3.Fuyang Inst Technol, Fuyang 236031, Anhui, Peoples R China
4.Chinese Acad Sci, Hefei Canc Hosp, Dept Pharm, Hefei 230031, Anhui, Peoples R China
5.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Intelligent Machines, Hefei 230031, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Cao, Chentai,Li, Pan,Liao, Hongmei,et al. Cys-functionalized AuNP substrates for improved sensing of the marine toxin STX by dynamic surface-enhanced Raman spectroscopy[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2020,412.
APA Cao, Chentai,Li, Pan,Liao, Hongmei,Wang, Junping,Tang, Xianghu,&Yang, Liangbao.(2020).Cys-functionalized AuNP substrates for improved sensing of the marine toxin STX by dynamic surface-enhanced Raman spectroscopy.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,412.
MLA Cao, Chentai,et al."Cys-functionalized AuNP substrates for improved sensing of the marine toxin STX by dynamic surface-enhanced Raman spectroscopy".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 412(2020).

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来源：合肥物质科学研究院

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