Selective Inhibition of BFL1: It's All about Finding the Right Partner
文献类型：期刊论文
| 作者 | Dai, Haiming1,2; Meng, X. Wei3,4; Kaufmann, Scott H.3,4 |
| 刊名 | CELL CHEMICAL BIOLOGY
 |
| 出版日期 | 2020-06-18 |
| 卷号 | 27 |
| ISSN号 | 2451-9448 |
| DOI | 10.1016/j.chembiol.2020.05.014 |
| 通讯作者 | Kaufmann, Scott H.(kaufmann.scott@mayo.edu) |
| 英文摘要 | In this issue of Cell Chemical Biology, Harvey et al. (2020) identify 4E14, a sulfhydryl-containing N-acetyltryptophan analog that selectively disrupts binding to the previously undruggable anti-apoptotic BCL2 paralog BFL1, and elucidate a BFL1 conformational change that facilitates 4E14 interaction. These results provide insight that will accelerate development of BFL1 inhibitors. |
| WOS关键词 | RESISTANCE ; BCL2A1 |
| 资助项目 | NCI[R01 CA166741] ; NCI[R01 CA172503] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000542791900003 |
| 出版者 | CELL PRESS |
| 资助机构 | NCI |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/71290]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Kaufmann, Scott H. |
| 作者单位 | 1.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Hlth & Med Technol, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China 2.Chinese Acad Sci, Hefei Canc Hosp, Hefei 230031, Peoples R China 3.Mayo Clin, Div Oncol Res, Rochester, MN 55905 USA 4.Mayo Clin, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN 55905 USA |
| 推荐引用方式 GB/T 7714 | Dai, Haiming,Meng, X. Wei,Kaufmann, Scott H.. Selective Inhibition of BFL1: It's All about Finding the Right Partner[J]. CELL CHEMICAL BIOLOGY,2020,27. |
| APA | Dai, Haiming,Meng, X. Wei,&Kaufmann, Scott H..(2020).Selective Inhibition of BFL1: It's All about Finding the Right Partner.CELL CHEMICAL BIOLOGY,27. |
| MLA | Dai, Haiming,et al."Selective Inhibition of BFL1: It's All about Finding the Right Partner".CELL CHEMICAL BIOLOGY 27(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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