Portable Smartphone Platform Integrated with a Nanoprobe-Based Fluorescent Paper Strip: Visual Monitoring of Glutathione in Human Serum for Health Prognosis
文献类型：期刊论文
| 作者 | Chu, Suyun1,3; Wang, Haiqian1; Du, Yuanxin4; Yang, Fan1,3; Yang, Liang1,2; Jiang, Changlong1,2
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| 刊名 | ACS SUSTAINABLE CHEMISTRY & ENGINEERING
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| 出版日期 | 2020-06-08 |
| 卷号 | 8 |
| 关键词 | Fluorescent sensor Visual monitoring Smartphone platform Glutathione Health prognosis |
| ISSN号 | 2168-0485 |
| DOI | 10.1021/acssuschemeng.0c00690 |
| 通讯作者 | Yang, Liang(yangliang@iim.ac.cn) ; Jiang, Changlong(cljiang@iim.ac.cn) |
| 英文摘要 | The glutathione (GSH) level in human serum is closely associated with several life-threatening diseases, and tracing the aberrant GSH level can monitor the subhealth conditions at an early stage for human health prognosis. Developing portable and direct read-out mini-devices is an inevitable trend for reliable point-of-care (POC) detection of GSH in real-time/on-site conditions. We herein report a portable smartphone-sensing platform, a ratiometric fluorescence sensor combined with the 3D-printed smartphone device for rapid, sensitive, quantitative, and on-the-spot determination of GSH in human serum. The powerful fluorescence "off-on" nanoprobe was constructed by mixing the blue carbon dots (CDs) and orange gold nanoclusters (AuNCs) with the assistance of copper ions. The quenched fluorescence can be quickly restored upon interacting with GSH, showing a distinct color variation from blue to purple to orange. Integrated with the paper strip printed by the probe ink, the smartphone platform installed with a Color Recognizer App could accomplish sensitive, reliable, and real-time/on-site detection of GSH in human serum, which shows great significance for early disease diagnosis. The constructed smartphone platform is expected to develop into portable home medical equipment to realize convenient and rapid preliminary monitoring and self-assessment of health. |
| WOS关键词 | CAPILLARY-ZONE-ELECTROPHORESIS ; AGGREGATION-INDUCED EMISSION ; SENSITIVE DETERMINATION ; FACILE PREPARATION ; CARBON DOTS ; PROBE ; CYSTEINE ; COMPLEX ; NANOCLUSTERS ; ASSAY |
| 资助项目 | National Natural Science Foundation of China[21876175] ; National Natural Science Foundation of China[21671052] ; National Natural Science Foundation of China[21605144] ; National Natural Science Foundation of China[21806168] ; Key Research and Development Program of Anhui Province[1804a07020103] ; Key Research and Development Program of Anhui Province[201904d07020001] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Engineering |
| 语种 | 英语 |
| WOS记录号 | WOS:000541445800010 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | National Natural Science Foundation of China ; Key Research and Development Program of Anhui Province |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/71272]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Yang, Liang; Jiang, Changlong |
| 作者单位 | 1.Chinese Acad Sci, Inst Solid State Phys, Hefei Inst Phys Sci, Hefei 230031, Anhui, Peoples R China 2.Chinese Acad Sci, State Key Lab Transducer Technol, Hefei 230031, Anhui, Peoples R China 3.Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China 4.Anhui Univ, Dept Chem, Hefei 230601, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chu, Suyun,Wang, Haiqian,Du, Yuanxin,et al. Portable Smartphone Platform Integrated with a Nanoprobe-Based Fluorescent Paper Strip: Visual Monitoring of Glutathione in Human Serum for Health Prognosis[J]. ACS SUSTAINABLE CHEMISTRY & ENGINEERING,2020,8. |
| APA | Chu, Suyun,Wang, Haiqian,Du, Yuanxin,Yang, Fan,Yang, Liang,&Jiang, Changlong.(2020).Portable Smartphone Platform Integrated with a Nanoprobe-Based Fluorescent Paper Strip: Visual Monitoring of Glutathione in Human Serum for Health Prognosis.ACS SUSTAINABLE CHEMISTRY & ENGINEERING,8. |
| MLA | Chu, Suyun,et al."Portable Smartphone Platform Integrated with a Nanoprobe-Based Fluorescent Paper Strip: Visual Monitoring of Glutathione in Human Serum for Health Prognosis".ACS SUSTAINABLE CHEMISTRY & ENGINEERING 8(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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