IP-10 and fractalkine induce cytotoxic phenotype of murine NK cells
文献类型：期刊论文
| 刊名 | SCIENCE BULLETIN
 |
| 出版日期 | 2016 |
| 卷号 | 61 |
| 关键词 | NATURAL-KILLER-CELLS IN-VIVO SIGNALING PATHWAY IMMUNE-RESPONSE MICE MICROENVIRONMENT CANCER CXCR3 INFILTRATION SUPPRESSES Chemokines NK cell Activating receptors Tumor microenvironment |
| ISSN号 | 2095-9273 |
| 英文摘要 | We characterized the murine NK cell subsets of the tumor microenvironment (TME) with low expressions of CD16 and NKG2D and investigated the chemokines that deter CD16(low) NKG2D(low) subsets. Our results demonstrated the activation of primary and KY-1 NK cell by ligands and found that exogenous CXCL10/interferon-gamma-induced protein 10 (IP-10) and fractalkine (FKN) can up-regulate the expression of CD16 and NKG2D. Moreover, both IP-10 and FKN are shown to facilitate migration, adhesion and cytotoxicity of NK cell subsets of the TME, due to the up-regulated CD16 and NKG2D. Overall, our data provide a new path by which to enhance murine NK cell cytotoxic potential and improve the quality of NK cells of the TME. |
| 资助项目 | [National Natural Science Foundation of China] ; [Tianjin Institutes for Basic Sciences] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5678550 |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/70228]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 推荐引用方式 GB/T 7714 | . IP-10 and fractalkine induce cytotoxic phenotype of murine NK cells[J]. SCIENCE BULLETIN,2016,61. |
| APA | (2016).IP-10 and fractalkine induce cytotoxic phenotype of murine NK cells.SCIENCE BULLETIN,61. |
| MLA | "IP-10 and fractalkine induce cytotoxic phenotype of murine NK cells".SCIENCE BULLETIN 61(2016). |
入库方式： OAI收割
来源：合肥物质科学研究院
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