Recent Advances in Chemical Synthesis of Backbone Cyclized Peptides
文献类型：期刊论文
| 刊名 | CHINESE JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2014 |
| 卷号 | 34 |
| 关键词 | SOLID-PHASE SYNTHESIS KINETICALLY CONTROLLED LIGATION TO-TAIL CYCLIZATION BIOMIMETIC SYNTHESIS STAUDINGER LIGATION CYCLATIVE CLEAVAGE THIOESTER PROTEINS TETRAPEPTIDES CYCLOTETRAPEPTIDES backbone cyclized peptides chemical synthesis native chemical ligation |
| ISSN号 | 0253-2786 |
| 其他题名 | Recent Advances in Chemical Synthesis of Backbone Cyclized Peptides |
| 英文摘要 | Backbone cyclized peptides belong to a family of circular polypeptide molecules in which the carboxyl and amino termini are covalently linked by an amide bond. Over the last almost 20 years, the backbone cyclized peptides have been discovered in bacteria, fungi, plants and animals. Compared with their linear precursors, the backbone cyclized peptides have a head-to-tail cyclic backbone enabling them to resist enzymatic degradation and to improve their thermal and chemical stability. Remarkably, some of them even have cell membrane permeability. Due to their exceptionally intracellular stability and potent bioactivities, backbone cyclized peptide is emerging as one of the most interesting molecules in the area of drug discovery. To study the structure and function of backbone cyclized peptides in detail, it is necessary to develop efficient approaches for the synthesis of these molecules. Herein, the recent advances in chemical synthesis of backbone cyclized peptides with respect to cyclization strategies are reviewed, including solid phase-based cyclization, liquid-phase cyclization, and intramolecular native chemical ligation. |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5113283 |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/68086]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 推荐引用方式 GB/T 7714 | . Recent Advances in Chemical Synthesis of Backbone Cyclized Peptides[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2014,34. |
| APA | (2014).Recent Advances in Chemical Synthesis of Backbone Cyclized Peptides.CHINESE JOURNAL OF ORGANIC CHEMISTRY,34. |
| MLA | "Recent Advances in Chemical Synthesis of Backbone Cyclized Peptides".CHINESE JOURNAL OF ORGANIC CHEMISTRY 34(2014). |
入库方式： OAI收割
来源：合肥物质科学研究院
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