Effect of a conserved peptide derived from Kunitz domain of hepatitis B virus x protein on the cell cycle and apoptosis of HepG2 cells via the proteasome pathway
文献类型：期刊论文
| 刊名 | CHINESE MEDICAL JOURNAL
 |
| 出版日期 | 2009 |
| 卷号 | 122 |
| 关键词 | UBIQUITIN-LIGATED PROTEINS ATPASE ACTIVITY EXPRESSION LEVEL SERINE-PROTEASE COMPLEX INHIBITOR P97 REPLICATION PROGNOSIS CARCINOMA peptides ubiquitin proteasome p97 valosin-containing protein carcinoma hepatocellular apoptosis |
| ISSN号 | 0366-6999 |
| 其他题名 | Effect of a conserved peptide derived from Kunitz domain of hepatitis B virus x protein on the cell cycle and apoptosis of HepG2 cells via the proteasome pathway |
| 英文摘要 | Background Hepatitis B virus (HBV) x protein (HBx) in HepG2 cells causes a moderate decrease in proteolysis activity of the proteasome. A highly conserved Kunitz-type serine protease inhibitor domain within 154 amino acid residues of HBx has been identified. In this study, a peptide chain derived from the Kunitz domain (PKD) was used to study its effect on the cell cycle and apoptosis of HepG2 cells, and investigated the function of PKD on the activities of proteasomes and AAA-ATPase p97, which involves in the ubiquitin-proteasome protein degradation pathway. |
| 语种 | 英语 |
| CSCD记录号 | CSCD:3591576 |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/67663]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 推荐引用方式 GB/T 7714 | . Effect of a conserved peptide derived from Kunitz domain of hepatitis B virus x protein on the cell cycle and apoptosis of HepG2 cells via the proteasome pathway[J]. CHINESE MEDICAL JOURNAL,2009,122. |
| APA | (2009).Effect of a conserved peptide derived from Kunitz domain of hepatitis B virus x protein on the cell cycle and apoptosis of HepG2 cells via the proteasome pathway.CHINESE MEDICAL JOURNAL,122. |
| MLA | "Effect of a conserved peptide derived from Kunitz domain of hepatitis B virus x protein on the cell cycle and apoptosis of HepG2 cells via the proteasome pathway".CHINESE MEDICAL JOURNAL 122(2009). |
入库方式： OAI收割
来源：合肥物质科学研究院
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